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Modulation Of Mitochondrial Complex I Activity Averts Cognitive Decline In Multiple Animal Models Of Familial Alzheimer'S Disease
Development of therapeutic strategies to prevent Alzheimer's disease (AD) is of great importance. We show that mild inhibition of mitochondrial complex I with small molecule CP2 reduces levels of amyloid beta and phospho-Tau ...
Cardiac Resynchronization Therapy Induces Adaptive Metabolic Transitions in the Metabolomic Profile of Heart Failure
(Churchill Livingstone Inc Medical Publishers, 2015)
Background: Heart failure (HF) is associated with ventricular dyssynchrony and energetic inefficiency, which can be alleviated by cardiac resynchronization therapy (CRT). The aim of this study was to determine the metabolomic ...