Now showing items 1-6 of 6
Differential Requirement For The Atpase Domain Of The Cockayne Syndrome Group B Gene In The Processing Of Uv-Induced Dna Damage And 8-Oxoguanine Lesions In Human Cells
(Oxford Univ Press, 2002)
Cockayne syndrome (CS) is a rare inherited human genetic disorder characterized by UV sensitivity, developmental abnormalities and premature aging. The cellular and molecular phenotypes of CS include increased sensitivity ...
In Vivo And In Vitro Effects Of A Hif-1 Alpha Inhibitor, Rx-0047
HIF-1 alpha plays a major role in activating gene transcription and is important for maintaining homeostasis under hypoxic conditions. Since tumors are often in a hypoxic state, HIF-1 alpha is a potential target for the ...
Misincorporation Of Free M-Tyrosine Cytotoxic Mechanism For Oxidized A Into Cellular Proteins: A Potential Amino Acids
(Portland Press Ltd, 2006)
In vitro studies demonstrate that the hydroxyl radical converts L-phenylalanine into in-tyrosine, an unnatural isomer of L-tyrosine. Quantification of m-tyrosine has been widely used as an index of oxidative damage in ...
Solid-Phase Enzyme Modification Via Affinity Chromatography
(Elsevier Science Bv, 2003)
In the present study antileukemic enzyme L-asparaginase (ASNase) and catalase (as a model enzyme) were modified in solid-phase with activated polyethylene glycol (PEG,) by using ligand-immobilized affinity column systems ...
Xeroderma Pigmentosum Complementation Group E Protein (Xpe/Ddb2): Purification Of Various Complexes Of Xpe And Analyses Of Their Damaged Dna Binding And Putative Dna Repair Properties
(Amer Soc Microbiology, 2005)
Xeroderma pigmentosum is characterized by increased sensitivity of the affected individuals to sunlight and light-induced skin cancers and, in some cases, to neurological abnormalities. The disease is caused by a mutation ...
Effects Of Cadmium And Zinc Ions On Purified Lamb Kidney Cortex Glucose-6-Phosphate Dehydrogenase Activity
(Taylor & Francis Ltd, 2006)
Glucose-6-phosphate dehydrogenase (G-6-PD) is the first enzyme in the pentose phosphate pathway. Cadmium is a toxic heavy metal that inhibits several enzymes. Zinc is an essential metal but overdoses of zinc have toxic ...