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In Vivo And In Vitro Effects Of A Hif-1 Alpha Inhibitor, Rx-0047
HIF-1 alpha plays a major role in activating gene transcription and is important for maintaining homeostasis under hypoxic conditions. Since tumors are often in a hypoxic state, HIF-1 alpha is a potential target for the ...
Xeroderma Pigmentosum Complementation Group E Protein (Xpe/Ddb2): Purification Of Various Complexes Of Xpe And Analyses Of Their Damaged Dna Binding And Putative Dna Repair Properties
(Amer Soc Microbiology, 2005)
Xeroderma pigmentosum is characterized by increased sensitivity of the affected individuals to sunlight and light-induced skin cancers and, in some cases, to neurological abnormalities. The disease is caused by a mutation ...