Non-Alkolik Yağlı Karaciğer (NAYKH) Hastalığı Olan Bireylerde Doymuş Yağı Azaltılmış Diyetin İnflamasyon Üzerine Etkisi
Erdem, Nur Bengü
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Erdem N.B., Effect of Reduced Saturated Fatty Acid Diet on Inflammation in Non-AlcoholicFatty Liver Disease (NAFLD), Hacettepe University Institue of Health Sciences of Nutritional Sciences, Master of Sciences Thesis, Ankara, 2017.Non-Alcoholic Fatty Liver Disease (NAFLD) is a complex disease that includes from; stetatosis known as a simple fatty liver to Non-Alcoholic Steatohepatitis, having inflamatuar situation and liver cancer.It has been showed that both of fat type and amount plays pioner role at the progression of disease.The aim of this study is to determine effect of reduced saturated fatty acids diet in anthropometric measurements some of biochemical parameters in blood Tumor necrosis factor (TNF) -α, Interleukin (IL)-6 and Chemerin levels in serum in individuals with NAFLD. A total of 23 adults aged between 19 to 65 years participated in the study. In this study regard individuals were randomly dividided into two groups. They followed diet therapy for three months; group with 7 % saturated fatty acid (n=11) 12% saturated fatty acid (n=12). Questionnairre including demographic characteristics,dietary habits, smoking status, alcohol consumption and 24 hour physical activity recall,were applied face to face at baseline. Collected serum samples for TNF-α, IL-6 and chemerin were run in by ELISA. Data of individiuals’s anthropometric measurements, biochemical parameters and serum protein levels were compared at baseline and end of study. Body Mass Index (BMI) decreased from 31,2±3,96 kg〖/m〗^2 to 29,3±4,36 kg〖/m〗^2(p=0,002) in 7 % saturated fatty acid group and from 29,9±3,90 kg〖/m〗^2 to 28,8±3,72kg〖/m〗^2 in 12 % saturated fatty acid group. (p=0,001)These changes were siginificant in statistically. At the end of study ALT, AST, enzyme level changes were significant (p<0,05). In both groups body weight, waist circumference and body fat percentage changes were significant in statistically (p<0,05). However TNF-α, IL-6 and chemerin levels changes weren’t significant in statistically (p>0,05). As a part of routin therapy importance of healthy nutrition should be explained to patients with NAFLD. Healhty nutrition habits can be applied long life should be aimed to patients with NAFLD.