Hacettepe İhsan Doğramacı Çocuk Hastanesi Çocuk Metabolizma Bilim Dalı’nda İzlenen Üre Döngüsü Bozukluğu Olan 85 Hastanın Klinik ve Laboratuvar Özelliklerinin Geriye Dönük İncelenmesi
Sarıtaş Nakip, Özlem
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Urea cycle disorders are a heterogeneous group of diseases that can manifest at any age. They are distinguished from other metabolic diseases by some unique findings. It is aimed to reduce morbidity and mortality with early diagnosis and treatment of the disease. This study retrospectively investigated patients with urea cycle disorders observed at the most experienced center of the metabolic disease in our country and identified the characteristics of the disease group in the country. Secondary goal of this study is to shed light on the research that will be carried out as well as being the largest patient group examined in our country until today. Eighty-five patients who were followed-up between 1979 and 2017 were included for the study, and also 131 hyperammonemic episodes were included. Among patients, citrullinemia type 1 was the most common type with 51.8%, ornithine transcarbamylase deficiency was the second with 24.7%, argininosuccinic aciduria was the third with 14,1%. The least common urea cycle disorders were carbamoyl phosphate synthase-1 deficiency, argininemia, and citrin deficiency. Of the 85 patients, 26 were lost to follow-up, 3 were followed by another center. Mean follow-up duration were 4.17 years (0 days-26.83 years). 30% of surviving patients had normal intelligence, while the rest were found to have developmental and mental retardation at various levels. 83,9% of the hyperammonemic episodes were recovered and the rest resulted with death. This study is thought to be a source for future studies.