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dc.contributor.advisorSamur, Fatma Gülhan
dc.contributor.authorAktaş, Ayşe
dc.date.accessioned2017-09-20T13:57:41Z
dc.date.available2017-09-20T13:57:41Z
dc.date.issued2017
dc.date.submitted2017-08-25
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dc.identifier.urihttp://hdl.handle.net/11655/3983
dc.description.abstractSerum ADMA level is a factor to determine cardiovascular diseases (CVD). It is hypothesized that individual nutritional status, dietary quality and dietary antioxidant composition may play a role in regulation of serum ADMA levels. This study was conducted to evaluate the relationship between nutritional status, diet quality and some anthropometric measurements and serum ADMA levels in 129 adult volunteers who were referred to Hacettepe University Faculty of Medicine, Cardiology Policlinic to undergoing coronary angiography. General characteristics, 24-hour food recall, nutritional status and diet quality scores (Healthy Eating Index/HEI) were evaluated after physical examination and some biochemical analyzes were performed. 30,2% of individuals were female, 69,8% were male and the average age was 63,0 ±10,0 years. According to body mass index (BMI), 48.8% of individuals were slightly fat and 32.6% were obese and BMI of female subjects were higher than male subjects (p <0.05). According to the Healthy Eating Index (HEI) there was no significant difference between the dietary qualities of male and female subjects (the average of HEI score was 61.3 ± 10.5 / normal diet quality) (p> 0.05). However, it was determined that inadequate total fruit and whole grain consumption and high sodium intake caused reduce diet quality score. Serum ADMA levels were higher in female subjects (1,3 ± 1,0 mol / L) than male subjects (1,2 ± 1,0 mol / L) (p> 0.05). There was negative correlation between serum ADMA level and dietary quality index and linear relationship between serum ADMA level and BMI and anthropometric measurements, but it was not statistically significant (p> 0.05). There is a need for studies showing an association between serum ADMA levels and anthropometric measurements such as BMI and waist circumference which are important risk factors for cardiovascular diseases.en
dc.description.sponsorshipBeslenme ve Diyetetik Bölümütr_TR
dc.description.tableofcontentsONAY SAYFASI iii YAYIMLAMA VE FİKRİ MÜLKİYET HAKLARI BEYANI iv ETİK BEYAN v TEŞEKKÜR vi ÖZET vii ABSTRACT viii İÇİNDEKİLER ix SİMGELER VE KISALTMALAR xi ŞEKİLLER xiii TABLOLAR xiii 1. GİRİŞ 1 1.1. Kuramsal Yaklaşımlar ve Kapsam 1 1.2. Amaç ve Varsayımlar 2 2. GENEL BİLGİLER 3 2.1. Koroner Arter Hastalığı Tanımı ve Epidemiyolojisi 3 2.2. Koroner Arter Hastalığı (KAH) Patofizyolojisi 5 2.3. Koroner Arter Hastalığının İnsidans ve Prevelansı 6 2.4. Koroner Arter Hastalığı Risk Faktörleri 7 2.4.1. Değiştirilebilir Risk Faktörleri 7 2.4.2. Değiştirilemeyen Risk Faktörleri 12 2.4.3. Yeni Risk Faktörleri 14 2.5. Asimetrik Dimetil Arjinin 16 2.5.1. Asimetrik Dimetil Arjinin (ADMA) ve Metabolizması 16 2.5.2. ADMA ve Kardiyovasküler Hastalıklar ile İlişkisi 18 2.5.3. Beslenme ve ADMA Düzeyi İlişkisi 20 2.5.4. Vücut Ağırlığının ADMA Düzeyine Etkisi 21 3. BİREYLER VE YÖNTEM 22 3.1. Araştırma Yeri, Zamanı ve Örneklem Seçimi 22 3.2. Araştırmanın Genel Planı 22 3.3. Verilerin Toplanması ve Değerlendirilmesi 23 3.3.1. Anket Formu 23 3.3.2. Fiziksel Aktivite Kaydı 24 3.3.3. Besin Tüketim Durumunun Saptanması 24 3.3.4. Sağlıklı Yeme İndeksi-2005 (SYİ) ve Değerlendirilmesi 25 3.3.5. Biyokimyasal Yöntemler 27 3.3.6. Verilerin İstatistiksel Açıdan Değerlendirilmesi 28 4. BULGULAR 29 4.1. Bireylere İlişkin Genel Özellikler 29 4.2. Bireylerin Beslenme Alışkanlıkları ve Besin Tüketim Sıklıklarının Değerlendirilmesi 34 4.3. Besin Tüketim Kayıtlarının Değerlendirilmesi 45 4.4. Bireylerin Diyet Kalitesinin Değerlendirilmesi 49 4.5. Bireylerin Antropometrik Ölçümlerinin Değerlendirilmesi 54 4.6. Bireylerin Biyokimyasal Bulgularına Göre Dağılımları 55 5. TARTIŞMA
 65 5.1. Bireylerin Genel Özelliklerinin Değerlendirilmesi 65 5.2. Bireylerin SYİ Puanlarının Değerlendirilmesi 67 5.3. Bireylerin Serum ADMA Düzeylerinin Değerlendirilmesi 73 5.3.1. Bireylerin Genel Özelliklerine Göre Serum ADMA Düzeylerinin Değerlendirilmesi 73 5.3.2. Antropometrik Ölçümler ile Serum ADMA Düzeyleri Arasındaki İlişkinin Değerlendirilmesi 74 5.3.3. Diyet Kalitesi ile Serum ADMA Düzeyleri Arasındaki İlişkinin Değerlendirilmesi 75 6. SONUÇ VE ÖNERİLER 78 7. KAYNAKLAR 82 8. EKLER EK-1: Tez Çalışması ile İlgili Etik Kurul İzinleri EK-2: Araştırma Amaçlı Çalışma İçin Aydınlatılmış Onam Formu EK-3. Anket Formu 9. ÖZGEÇMİŞtr_TR
dc.language.isoturtr_TR
dc.publisherSağlık Bilimleri Enstitüsütr_TR
dc.rightsinfo:eu-repo/semantics/restrictedAccesstr_TR
dc.subjectKoroner Arter Hastalığıtr_TR
dc.subjectSağlıklı Yeme İndeksitr_TR
dc.subjectBeslenme Durumutr_TR
dc.subjectAsimetrik Dimetil Arjinintr_TR
dc.titleKoroner Arter Hastalarında Beslenme Durumu ile Serum Asimetrik Dimetil Arjinin (ADMA) Düzeyi Arasındaki İlişkitr_TR
dc.typeinfo:eu-repo/semantics/masterThesisen
dc.description.ozetSerum asimetrik dimetil arjinin (ADMA) düzeyi kardiyovasküler hastalıklar (KVH) için tanımlayıcı bir faktördür. Bireylerin beslenme durumu, diyet kalitesi ve diyetin antioksidan bileşiminin serum ADMA düzeyinin düzenlenmesinde rolü olduğu düşünülmektedir. Bu çalışma, koroner arter hastalığı (KAH) tanısı almış bireylerin beslenme durumu, diyet kaliteleri, ve bazı antropometrik ölçümleri ile serum ADMA düzeyleri arasındaki ilişkinin değerlendirilmesi amacıyla Hacettepe Üniversitesi Tıp Fakültesi Kardiyoloji Polikliniğinde koroner anjiyografiye yönlendirilen gönüllü 129 yetişkin birey üzerinde yapılmıştır. Klinikte, fizik muayeneleri yapılan bireylerin genel özellikleri, 24 saatlik besin tüketimleri, beslenme durumları ve diyet kalite skorları (Sağlıklı Yeme İndeksi/ SYİ) değerlendirilmiş, bazı biyokimyasal analizleri yapılmıştır. Bireylerin %30,2’i kadın, %69,8’i erkek olup yaş ortalamaları 63,00±10,00’dur. Bireylerin beden kütle indeksine (BKİ) göre %48,8’i hafif şişman, %32,6’ı şişman olup kadın bireylerin BKİ ortalamaları erkek bireylerden daha yüksek bulunmuştur (p<0,05). Sağlıklı Yeme İndeksi (SYİ)’ne göre kadın ve erkek bireylerin diyet kaliteleri (SYİ puanı ortalama 61,3 ± 10,5/ diyet kalitesi normal) arasında önemli bir fark gözlenmemiştir (p>0.05). Ancak SYİ’e göre bireylerin toplam meyve ve tam tahıl tüketiminin yetersiz, sodyum alımının ise yüksek olmasının diyet kalite puanını düşürdüğü saptanmıştır. Kadın bireylerin serum ADMA düzeyi (1,3±1,0 mol/L) erkek bireylerden (1,2±1,0 mol/L) daha yüksek bulunmuştur (p>0.05). Serum ADMA düzeyi ile diyet kalite indeksi arasında negatif, BKİ ve antropometrik ölçümlerle doğrusal yönlü olarak saptanan ilişki istatiksel olarak önemli bulunmamıştır (p>0.05). Kardiyovaskuler hastalıklar için önemli risk faktörleri olan diyet kalitesi, BKİ ve bel çevresi gibi antropometrik ölçümlerle serum ADMA düzeyi arasında ilişkiyi gösteren çalışmalara ihtiyaç vardır.tr_TR
dc.contributor.departmentBeslenme ve Diyetetiktr_TR
dc.contributor.authorID229523tr_TR


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