• Türkçe
    • English
  • English 
    • Türkçe
    • English
  • Login
View Item 
  •   DSpace Home
  • Eczacılık Fakültesi
  • Eczacılık Teknolojisi Bölümü
  • Eczacılık Teknolojisi Bölümü Tez Koleksiyonu
  • View Item
  •   DSpace Home
  • Eczacılık Fakültesi
  • Eczacılık Teknolojisi Bölümü
  • Eczacılık Teknolojisi Bölümü Tez Koleksiyonu
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Rivaroksaban Nanokristallerinin Hazırlanması ve İn Vitro - İn Vivo Değerlendirilmesi

Thumbnail
View/Open
Doktora Tezi (6.360Mb)
Date
2018-04-27
Author
Demir Kabaş, Huriye
xmlui.mirage2.itemSummaryView.MetaData
Show full item record
Abstract
The aim of this thesis is to solve the dose-proportionality problem encountered in high doses as a result of low solubility of rivaroxaban (RXB) which is a direct factor Xa inhibitor and a Biopharmaceutical Classification System Class II drug. To increase the solubility of RXB, its nanocrystal formulations were prepared and their physicochemical characterizations were examined. Pluronic F 127 and Pharmacoat 603 were used as the stabilizers to prepare nanosuspensions with a combination of ultra turrax, ball mill and high pressure homogenization methods. With nanocrystal technology, the particle size is reduced, the in vitro dissolution and permeability coefficient is increased. The presence of crystal structure and the chemical structure of RXB have been found to be preserved. The nanosuspension formulation with the best particle size distribution, in vitro dissolution profile and permeability results was applied by oral gavage to rabbits at doses of 3 mg / kg, 10 mg / kg and 15 mg / kg. Plasma RXB levels were determined by LC / MS / MS method. The area under the curve and the maximum plasma concentration parameters were evaluated in terms of dose proportionality. The results obtained from simple linear regression, analysis of variance and equivalence criterion methods showed that dose proportionality between 3 mg-15 mg and 10 mg -15 mg doses were achieved.
URI
http://hdl.handle.net/11655/4482
xmlui.mirage2.itemSummaryView.Collections
  • Eczacılık Teknolojisi Bölümü Tez Koleksiyonu [32]
Hacettepe Üniversitesi Kütüphaneleri
Açık Erişim Birimi
Beytepe Kütüphanesi | Tel: (90 - 312) 297 6585-117 || Sağlık Bilimleri Kütüphanesi | Tel: (90 - 312) 305 1067
Bizi Takip Edebilirsiniz: Facebook | Twitter | Youtube | Instagram
Web sayfası:www.library.hacettepe.edu.tr | E-posta:openaccess@hacettepe.edu.tr
Sayfanın çıktısını almak için lütfen tıklayınız.
Contact Us | Send Feedback



DSpace software copyright © 2002-2016  DuraSpace
Theme by 
Atmire NV
 

 


DSpace@Hacettepe
huk openaire onayı
by OpenAIRE

About HUAES
Open Access PolicyGuidesSubcriptionsContact

livechat

sherpa/romeo

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsTypeDepartmentPublisherLanguageRightsIndexing SourceFundingxmlui.ArtifactBrowser.Navigation.browse_subtypeThis CollectionBy Issue DateAuthorsTitlesSubjectsTypeDepartmentPublisherLanguageRightsIndexing SourceFundingxmlui.ArtifactBrowser.Navigation.browse_subtype

My Account

LoginRegister

Statistics

View Usage Statistics

DSpace software copyright © 2002-2016  DuraSpace
Theme by 
Atmire NV