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DİYABET HASTALARINDA MİNERAL TRİOKSİT AGREGAT/1α,25-DİHİDROKSİVİTAMİN D3 KOMBİNASYONU İLE DENTAL PULPA KÖK HÜCRELERİNDE ODONTOJENİK FARKLILAŞMANIN ARAŞTIRILMASI
(Sağlık Bilimleri Enstitüsü, 2021-01-15)Dental treatments in diabetic patients have been reported to fail in the long term and these patients have more tooth extraction. It is aimed to investigate the odonto/osteogenic differentiation potential of the combination ... -
Parkinson Hastalığı Hücresel Modelinde İnflamasyonun ve İnflamasyon Sonrası Uygulanan N-Asetilsisteinin H4 Hücrelerindeki Lag3 ve Tlr2 Reseptörleri Üzerine Etkisi
(Sağlık Bilimleri Enstitüsü, 2021)Kaya, Z.B., The Effect of Inflammation and Post-Inflammatory Administration of N-Acetylcysteine on LAG3 and TLR2 Receptors on H4 Cells in the Cellular (In Vitro) Model of Parkinson's Disease, Hacettepe University Graduate ... -
Antioksidan Kullanımının Meme Kanseri Tedavisi Üzerindeki Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2021-01-20)Drug resistance against chemotherapy is one of the main factors limitating the success of cancer treatment. Several studies have reported that the expression level of the glutathione S-transferase P1 (GSTP1) isozyme from ... -
İnsan Serum Bütirilkolinesterazının Olası Lipolitik Aktivitesi-Lipid Metabolizması ile İlişkisi.
(Sağlık Bilimleri Enstitüsü, 2021-01-21)Cholinesterases (AChE and BChE) terminate acetylcholine-induced neurotransmission at cholinergic synapses in muscle-nerve junctions. We previously showed BChE expression is regulated by essential fatty acids. The similarity ... -
Investigation of the Role of LAP1B in Transcriptional Regulation of Muscle Cells
(Sağlık Bilimleri Enstitüsü, 2021-01-20)The loss-of-function of the inner nuclear membrane protein LAP1B (lamina-associated polypeptide 1, isoform B) causes muscular dystrophy and cardiomyopathy in humans. The function of LAP1B in muscle is still unknown. The ... -
MOLECULAR PROPERTIES OF CRAYFISH POTASSIUM CHANNELS
(Sağlık Bilimleri Enstitüsü, 2021)Ergin, B., Molecular Properties of Crayfish Potassium Channels. Hacettepe University Graduate School of Health Sciences, Ph.D. Thesis in Biophysics, Ankara, 2021. Potassium channel family is the largest group in the ion ... -
İlaç Yeniden Konumlandırma Yaklaşımı ile Alfa Tübülin Asetilasyonunu Arttırabilecek Bileşiklerin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2020)Drug repurposing approach is used to identify new indications of drugs outside the scope of their original indications. This approach has been used to identify effective compounds for neurodegenerative diseases. Axonal ... -
Müfredat-I Tıbbı̇ye (1290/Hı̇crı̇) Adlı Yazma Eserde Geçen Bazı Bı̇tkı̇Lerı̇n Tıp Tarı̇hı̇ Açısından Değerlendı̇rilmesı̇
(Sağlık Bilimleri Enstitüsü, 2020)The work titled “Müfredat-ı Tıbbiye” consists of lecturers written by Veterinarian İsmail Hilmi Bey. The only known copy is in the Koyunoğlu Museum. The date of writing is specified as 1290 Arabi by İsmail Hilmi Bey's ... -
Çocuk Yanık Yoğun Bakım Ünitesi Yatak Başı Klinik Ekip Vizitlerinde Çocuk Cerrahi Asistanlarının Vizit Yönetim Becerilerinin Değerlendirilmesi ve Klinik Vizit Sürecinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2020-09)The research was carried out in a mixed design in order to examine the process of (clinical) pediatric surgical physician visits performed in the Pediatric Burn Intensive Care Unit and to evaluate the bedside round management ... -
AEBP1/ACLP'nin Protein Etklileşim Ağının Proteomik ve Biyoinformatik Yöntemlerle Araştırılması
(Sağlık Bilimleri Enstitüsü, 2020)Extracellular Matrix (ECM) is the mechanical supportive structure for cells and tissues. Chronic damage may cause loss of ECM integrity that may result in fibrosis which is the progressive and irreversible accumulation of ... -
Spinal Müsküler Atrofi Hastalarının Fibroblast Kültürlerinde Mikrotübül Stabilitesinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2020)Spinal muscular atrophy (SMA), which is characterized by motor neuron loss and muscle atrophy, is a neurodegenerative disease primarily in childhood. In SMA, Survival of motor neuron 1 (SMN1) gene mutations lead to the ... -
Mikrodizi Gen İfade Verilerinde Farklı Öznitelik Seçim Yöntemleri ile Sınıflama Yöntemlerinin Performanslarının Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2020-08-07)Bioinformatics is an interdisciplinary branch of science that combines statistics, biology, computing, mathematics, and genetics, and thanks to the analysis in bioinformatics, it can be shown which abnormalities causes ... -
Determination of Lipid Metabolism Alterations and Their Association with Disease Pathogenesis in Sickle Cell Disease
(Sağlık Bilimleri Enstitüsü, 2020-07-07)Sickle cell disease (SCD) is a hemoglobinopathy that causes severe anemia and is characterized by lipid abnormalities, oxidative stress and chronic inflammation. It is caused by a single point-mutation in the beta globin ... -
Bisfenol A’nın Hepg2 Hücrelerine Olan Etkilerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2020)Öz, E. Examination of the Effects of Bisphenol A on HepG2 Cells. Hacettepe University Graduate School of Health Sciences, Biochemistry Program, Master Thesis, Ankara, 2020. In this study, it was aimed to determine the ... -
Biyotıpta Gelişen Teknolojilerdeki Etik ve İnsan Hakları Sorunları
(Sağlık Bilimleri Enstitüsü, 2020)Close interaction between life and engineering sciences, emerging nanotechnologies, biotechnologies, information communication technologies, and the use of neurotechnology in medicine have led to the development of new ... -
Improvement of Germ Stem Cell Pool by Leptin Supplementation and Gene Editing for Male Infertility
(Sağlık Bilimleri Enstitüsü, 2020-06-12)Infertility affects up to 12-15% of sexually active couples, and male factors contribute about 30-55% of these cases. Infertility can be caused by injuries, genetic factors, exposure to toxicants, immune-suppressive and ... -
TROMBOSİTOPENİK HASTALARDA PLATELET YÜZEY ANTİJENLERİNİN AKIM SİTOMETRİ İLE İNCELENMESİ VE KANAMA DİYATEZİ İLE İLİŞKİSİNİN ARAŞTIRILMASI
(Tıp Fakültesi, 2019)Bleeding is mainly associated with low platelet counts and platelet dysfunctions. Although there are several methods to evaluate platelet function, they require large amount of blood and platelet counts more than 150.000/µl. ... -
Çocukluk Çağı Arterial İskemik İnmeleri Ve Sinövenöz Trombozlarında İlişkili Faktörler, Etiyolojinin Belirlenmesi ve Nörolojik Sonuçlar
(Tıp Fakültesi, 2017-09)Pediatric stroke is rare compared to adults, however causes long term morbidity and mortality. We retrospectively analysed children beyond newborn period, diagnosed with acute stroke and followed up at Hacettepe University ... -
Mycobacterium Tuberculosis Klinik İzolatlarında Yeni Antitüberküloz İlaçlar Olan Bedaquiline ve Delamanid'in MİK Değerlerinin ve Dirence Neden Olan Mutasyonların Saptanması
(Sağlık Bilimleri Enstitüsü, 2020)The purpose of this study is to detect the minimum inhibitory concentration (MIC) values of these novel drugs against to 101 resistant-M.tuberculosis clinical isolates with MGIT 960 automatized liquid culture system ... -
Fenilketonüride Öğrenme Bellek Mekanizmasının Dişi Ve Erkek Sıçanlarda cAMP/PKA/CREB/BDNF Yolağı Üzerinden İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2020)Phenylketonuria is a rare hereditary metabolic disease characterized by deficiency of phenylalanine hydroxylase. The absence of enzyme causes blood phenylalanine levels to rise. If patients are not treated, irreversible ...
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