Browsing Temel Tıp Bilimleri Bölümü Tez Koleksiyonu by Issue Date
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Bilgi Kuramı Yaklaşımı ile Bilgisayarlı Tomografik Koroner Anjiyografinin Tanısal Değerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2012)Classical performance measures of a test, such as sensitivity, specificity, positive predicted value (PPV) and negative predicted value (NPV), are obtained by comparison of the test results with a gold standard test. This ... -
Kistik Fibrozisli Hastalarda Anaerop Bakterilerin Rolünün Araştırılması
(Tıp Fakültesi, 2012)Pseudomonas aeruginosa, Staphylococcus aureus, Haemophilus influenzae and Burkholderia cepacia complex are the most frequently isolated microorganisms from respiratory tract samples of the cystic fibrosis patients. ... -
Nörofibromatozis Tip1 ile İlişkili Tümörlerde Koronin 1A İfadesinin Belirlenmesi
(Sağlık Bilimleri Enstitüsü, 2012)Neurofibromatosis Type 1 (NF1) is an autosomal dominant disorder characterized by pigmentation abnormalities, failure of skeleton and cardiovascular system with predisposition of tumorogenesis. Nf1 gene product neurofibromin ... -
Çocukluk Dönemi Steroide Dirençli Nefrotik Sendroma Sebep Olan Yeni Genlerin Bulunması
(Sağlık Bilimleri Enstitüsü, 2012)Steroid resistant nephrotic syndrome (SRNS), despite being a rare disease, is the second most common cause of end stage kidney failure in childhood and early adulthood. However the heterogeneity and rarity (<1%) of disease ... -
Desmin Geni C.1289-2a>G Mutasyonunun Desmin Proteinine Etkisinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2012)Autosomal recessive limb girdle muscular dystrophy (LGMD2) is clinically and genetically heterogeneous group of diseases that are characterized by progressive atrophy and weakness of proximal muscles. Two siblings of a ... -
Kolşisinin Pyrin ve Pyrin ile Ilişkili Proteinler Üzerine Etkisi
(Sağlık Bilimleri Enstitüsü, 2012)MEFV which encodes pyrin, causes familial Mediterranean fever (FMF), the most common auto-inflammatory disease. Pyrin is believed to be a regulator of inflammation, though the nature of this regulatory activity remains to ... -
Ankara Bölgesinde Batı Nil Virusu ve Toskana Virus Vektörlerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2013)West Nile Virus (WNV) and Toscana virus (TOSV) may cause febrile diseases and central nervous system infections and even severe meningoencephalitis in susceptible individuals. Major transmission route is via blood sucking ... -
Gestasyonel Diyabetli Gebe Plasentalarında Aqp8 ve Aqp9 Dağılımlarının İncelenmesi
(Tıp Fakültesi, 2013)During pregnancy, fetal water requirements increase markedly due to the exponential growth of fetus. Physiological data indicate that both a transcellular and a paracellular pathway are available for water transport across ... -
Metakromatik Lökodistrofi: Üç Arilsülfataz A Mutasyonunun (P.307Glu→Lys, P.318Trp→Cys Ve C.1165G Delesyonu) Arilsülfataz A Aktivitesi Ve Arilsülfataz A Proteini Üzerine Etkisinin Tanımlanması
(Tıp Fakültesi, 2013)Metachromatic leukodystrophy (MLD) is an autosomal recessively inherited sphingolipid storage disease that occurs as a result of a lack of lysosomal enzyme Arylsulfatase A (ASA) or its activator protein. In this study, two ... -
İzole Edilmiş Sıçan Pankreas Adacık Hücrelerine in Vitro Trombospondinin Etkisi
(Sağlık Bilimleri Enstitüsü, 2013)Pancreas islet cells are very sensitive to hypoxic stress because of having small amount of anti-oxidant enzyme. Loss of islet cell viability due to hipoxic damage decreases success of transplantation. Islet- endothelial ... -
Mycobacterium Tuberculosis Klinik İzolatlarında İlaç Direncinin Multipleks Real-Time Pcr Yöntemiyle Saptanması
(Sağlık Bilimleri Enstitüsü, 2013)Tuberculosis (TB) is stil one of the most serious threats to human health around the world. Increasing of the drug resistance is one of the main cause of this state. Early diagnosis of drug-resistant TB cases is urgently ... -
Nörofibromatozis Tip 1 ile İlişkili Tümörlerde C-X-C Kemokin Reseptör Tip 4 Gen İfade Düzeyinin Belirlenmesi
(Sağlık Bilimleri Enstitüsü, 2013)Neurofibromatosis type 1 (NF1) is a common genetic disorder that affects skin and nervous system that is inherited in autosomal dominant trait. It occurs due to the mutations in NF1 gene. The most common Schwann cell ... -
Mikroarray Gen Ekspresyon Veri Setlerinde Random Forest Ve Naıve Bayes Sınıflama Yöntemleri Yaklaşım
(Sağlık Bilimleri Enstitüsü, 2013)Two classification methods,Random Forest and Naive Bayes,were compared about various types of cancer -
Lizozomal Depo Hastalığı Olan Gaucher Hastalığında Otofaji Mekanizmasının Moleküler Düzeyde İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2013)Lysosomes are the most important degradation organelles of the cell. The functions of the lysosomes depend upon the harmonious coordination between the lysosomal hydrolases and the lysosomal membrane proteins existing in ... -
Spinal Müsküler Atrofi Patogenezinde Rol Alan Genetik Düzenleyicilerin İfade Analizi
(Sağlık Bilimleri Enstitüsü, 2013)Childhood- onset spinal muscular atrophy (SMA) is an autosomal recessive disorder, which leads to alpha motor neuron degeneration. Although 95-98 % of the patients have homozygous deletions in exon 7 and 8 SMN1 gene, ... -
Hukuki ve Etik Yönleri ile Biyotıp Araştırmalarında Biyobankalar
(Sağlık Bilimleri Enstitüsü, 2013)Biobanks are the organizations where biological materials and associated personal information are collected, stored, processed and distributed in a particular systematic. Biobanks provide opportunity to easily obtain enough ... -
Polikistik Over Sendromunun Patogenezinde Progranulin ve Tnf-Alfa Nın Rolü
(Tıp Fakültesi, 2013)Polycystic ovary syndrome (PCOS) is chacterized by menstrual irregularities, hirsutism, acne and obesity. Chronic and subclinic inflammation, insulin resistance are the basic pathological mechanisms of PCOS. Tumor necrosis ... -
Otoimmun ve Vasküler Hastalıklarda Erken Dönemde Endometriyum Reseptivitesinin Değerlendirilmesi
(Tıp Fakültesi, 2013)At each monthly cyle, endometrium undergoes structural changes and renews itself under hormonal control. A healthy endometrium is necessary for a succesful implantation and pregnancy. Implantation depends on the interaction ... -
Sutura Sphenovomeralıs' ın Endoskopik Transsphenoidal ve Radyolojik Yöntemlerle Incelenmesi
(Tıp Fakültesi, 2013)Rostrum of sphenoid bone articulates with ala of vomer forming schindylesis type of joint. The circumference of this joint is called sphenovomerine suture (SSV). Although this suture is mentioned in Terminologia Anatomica, ... -
Otoimmün Hepatitli Hastalarda Hepatik Fibrozis Düzeyinin Değerlendirilmesinde Elf Testi ile Karaciğer Biyopsisinin Tanısal Değerlerinin Karşılaştırılması
(Tıp Fakültesi, 2013)Autoimmune hepatitis is a chronic inlammatory disease characterized by hepatomegaly, presence of autoantibodies and polyclonal hypergammaglobulinemia. As a chronic liver disease, fibrosis is one of the complications of ...
