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KİŞİYE ÖZEL KRANİYAL İMPLANTLARDA YAPISAL PARAMETRELERİN ARAŞTIRILMASI: SONLU ELEMANLAR ANALİZİ UYGULAMASI
(Fen Bilimleri Enstitüsü, 2020)Cranioplasty is a surgical procedure for repairing skull defects. These defects can be caused by congenital defects, diseases, accidents, infections or tumors. Cranioplasty, ensuring the integrity of the skull, not only ... -
Kişiye Özel Temporamandibular Eklem Protezinin Tasarlanması ve Katmanlı İmalat Teknolojisi ile Üretimi
(Fen Bilimleri Enstitüsü, 2019-10-22)The Temporomandibular Joint (TMJ) is a small joint located at the junction of the skull and the lower jaw in front of the ear. It provides movement and function of the lower jaw (mandible). Any damage (usually trauma, ... -
Optical Assays Based on Colloidal Inorganic Nanoparticles
(Royal Soc Chemistry, 2018)Colloidal inorganic nanoparticles have wide applications in the detection of analytes and in biological assays. A large number of these assays rely on the ability of gold nanoparticles (AuNPs, in the 20 nm diameter size ... -
Investigation Of Waste Paper-Derived Carbon Aerogel/Elastomer System As A Cardiac Patch
(Fen Bilimleri Enstitüsü, 2019-09-30)Cardiovascular diseases (CVDs) are blamed for the major number of deaths around the world. Among of these is Myocardial Infarction (MI) which occurs when the flow of the blood through one of the coronary arteries is ... -
E. coli Tayini İçin Altın Selüloz Nanofibril Materyal Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2019)In this thesis, a method for the detection of Escherichia coli (E. coli) bacteria was developed using Raman techniques and Raman mapping methods. Firstly, gold nanorod particles were synthesized and subsequently surface ... -
Mikrodalga Desteği İle Metakrilatlanmış Kappa Carrageenan Hidrojellerin 3B Baskılanması ve Kıkırdak Doku Mühendisliğinde Kullanımının Araştırılması
(Fen Bilimleri Enstitüsü, 2019)This “3D Bioprinting of Microwave Assisted Methacrylated Kappa Carrageenan Hydrogels and Investigation of Their Usage in Cartilage Tissue Engineering” entitled study was supported by the The Scientific and Technological ... -
Kanser Tedavisinde Gen Susturulması İçin Hyalüronik Asit-Polietilenimin Taşıyıcı Sisteminin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2019)Target-specific delivery of small interfering siRNAs in cancer treatment is one of today's leading research topics. Within the scope of the thesis, effective transport of siRNAs via hyaluronic acid (HA) receptor was carried ... -
Effectiveness Of Single And Dual Release Of Melatonin And Bmp-2 In Bone Homeostasis
(Fen Bilimleri Enstitüsü, 2019)In the present thesis, it was aimed to develop single and dual release systems to achieve the prolonged delivery of melatonin (MEL) and bone morphogenetic protein two (BMP-2) and to investigate their synergistic effect on ... -
Tiyol-Metakrilat Polimerizasyonu ile Affinite Monolitlerinin Sentezi ve Histidin İşaretli Protein İzolasyonunda Kullanımı
(Fen Bilimleri Enstitüsü, 2019-06-19)There are many methods currently available for the purification of proteins. It is important that the purification process is carried out in as little steps as possible, with high purity and in a short time. Therefore, ... -
Akciğer Kanserinde Kannabinoidlerin CB Reseptörleri Aracılı Antiproliferatif ve Proapoptotik Etkisinin Araştırılması
(Fen Bilimleri Enstitüsü, 2019-07-04)Lung cancer is the most common cause of death among all cancers in the world due to its rapid metastasis and late diagnosis. Non-small cell lung cancer (NSCLC) constitutes 80% of lung cancer cases. Endocannabinoids are ... -
Meme Kanseri Hücreleriyle Üç Boyutlu Tümör Modellerinin Geliştirilmesi ve Noç Reseptörü İnhibitörünün Uygulanması
(Fen Bilimleri Enstitüsü, 2019-06-28)Tissue cultures as disease models are indispensable research tools in the preclinical studies. Two-dimensional (2D) culture that composed in the monolayer form cannot bear the extracellular interactions of the natural ... -
Kemik Çimentolarında Yumurta Kabuğu Zarı Proteininin Kullanımı
(Fen Bilimleri Enstitüsü, 2019-10-07)Within the scope of the presented thesis, it is thought that protein doped bone cements promise potential in terms of biodegradability and strength. Therefore, by adding protein to calcium sulphate based bone cements (CSC), ... -
Osseintegrasyonu Arttıracak Hidroksiapatit/Siklodekstrin Kompozit Taşıyıcıların Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2015)ABSTRACT DEVELOPMENT OF HYDROXYAPATITE/CYCLODEXTRIN COMPOSITE CARRIERS TO ENHANCE OSSEOINTEGRATION Meryem Sümeyye AKDEMİR Master of Science, Bioengineering Division Supervisor: Prof. Dr. Menemşe ... -
Hücre Tabakası Mühendisliğinde Kalınlık ve Vaskülerizasyon Problemlerine Yönelik Stratejilerin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2019)In the context of tissue engineering studies, various biomaterials, cells and biosignal molecules have been used to repair and replace diverse tissues either alone or in combination, namely to produce tissue-engineered ... -
SALİNOMİSİN ve BnHAp YÜKLÜ DOKU İSKELELERİNİN ANTİKANSEROJEN ve ANTİBAKTERİYEL ETKİNLİĞİNİN ARAŞTIRILMASI
(Fen Bilimleri Enstitüsü, 2018)In the scope of the thesis, it is aimed to investigate the synergistic effect of an anticancer drug, salinomycin, loaded poly (lactic-co-glycolic acid) (PLGA 65:35) nanoparticles with the boron doped nanohydroxyapatite ... -
Adipoz Kökenli Mezenkimal Kök Hücrelerin Polietilenglikol Dimetakrilat Hidrojellerde Kahverengi ve Beyaz Adipoz Dokuya Farklılaşmalarının İncelenmesi
(Fen Bilimleri Enstitüsü, 2019-02)This study was financially supported by Hacettepe University Scientific Research Projects Coordination Unit with a graduate project entitled “Investigation of Brown and White Adipose Tissue Differentiation of Adipose Derived ... -
3 Boyutlu Yazıcı ile Metakrilatlanmış Jelatin/PRP Hidrojel ve Mezenkimal Kök Hücre İçeren Osteokondral Gradyan Sistemlerin Hazırlanması ve in-Vitro Etkinliklerinin Belirlenmesi
(Fen Bilimleri Enstitüsü, 2019)The aim of the presented doctoral thesis is to develop a gradient hydrogel system which loaded adipos tissue derived stem cells (AdMSCs) by using photoactivated platelet-rich plasma (PRP) gradient and 3D bioprinting method ... -
Hücrelerinden Arındırılmış Miyokardiyal Doku İle Hücre Tabakası Destekli Kalp Yaması Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2019-02)The aim of this thesis is to produce a heart patch by combining cardiovascular cell sheet and decellularized myocardial extracellular matrix (ECM). In the study, two innovative approaches of tissue engineering, ‘‘cell sheet ... -
Development And Characterisation Of Magnetically Responsive And Active Agent Loaded Alginate Based Microspheres To Be Used In The Treatment Of Hepatocellular Carcinoma (Hcc)
(Fen Bilimleri Enstitüsü, 2019)Today, cancer is the foremost common and deadly disease in the world. One of the most important cancer types is liver cancer and occurs either by being directly involved with liver cells resulting in primary liver cancers, ... -
Poli(Poliol)Sebakat Bazlı Biyobozunur Elastomerlerin Sentezi ve Jiro Eğrilmiş Fiber Destekli Hidrojel Doku İskelelerinin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2019)Poly(polyol) sebacate (PPS) based polymers are promising polymers in biomedical and tissue engineering field, thanks to tunable mechanical properties and having biodegradable and biocompatible features. However, difficult ...
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