Biyomühendislik Bölümü
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Hücre Tabakası Mühendisliğinde Kalınlık ve Vaskülerizasyon Problemlerine Yönelik Stratejilerin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2019)In the context of tissue engineering studies, various biomaterials, cells and biosignal molecules have been used to repair and replace diverse tissues either alone or in combination, namely to produce tissue-engineered ... -
SALİNOMİSİN ve BnHAp YÜKLÜ DOKU İSKELELERİNİN ANTİKANSEROJEN ve ANTİBAKTERİYEL ETKİNLİĞİNİN ARAŞTIRILMASI
(Fen Bilimleri Enstitüsü, 2018)In the scope of the thesis, it is aimed to investigate the synergistic effect of an anticancer drug, salinomycin, loaded poly (lactic-co-glycolic acid) (PLGA 65:35) nanoparticles with the boron doped nanohydroxyapatite ... -
Adipoz Kökenli Mezenkimal Kök Hücrelerin Polietilenglikol Dimetakrilat Hidrojellerde Kahverengi ve Beyaz Adipoz Dokuya Farklılaşmalarının İncelenmesi
(Fen Bilimleri Enstitüsü, 2019-02)This study was financially supported by Hacettepe University Scientific Research Projects Coordination Unit with a graduate project entitled “Investigation of Brown and White Adipose Tissue Differentiation of Adipose Derived ... -
3 Boyutlu Yazıcı ile Metakrilatlanmış Jelatin/PRP Hidrojel ve Mezenkimal Kök Hücre İçeren Osteokondral Gradyan Sistemlerin Hazırlanması ve in-Vitro Etkinliklerinin Belirlenmesi
(Fen Bilimleri Enstitüsü, 2019)The aim of the presented doctoral thesis is to develop a gradient hydrogel system which loaded adipos tissue derived stem cells (AdMSCs) by using photoactivated platelet-rich plasma (PRP) gradient and 3D bioprinting method ... -
Hücrelerinden Arındırılmış Miyokardiyal Doku İle Hücre Tabakası Destekli Kalp Yaması Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2019-02)The aim of this thesis is to produce a heart patch by combining cardiovascular cell sheet and decellularized myocardial extracellular matrix (ECM). In the study, two innovative approaches of tissue engineering, ‘‘cell sheet ... -
Development And Characterisation Of Magnetically Responsive And Active Agent Loaded Alginate Based Microspheres To Be Used In The Treatment Of Hepatocellular Carcinoma (Hcc)
(Fen Bilimleri Enstitüsü, 2019)Today, cancer is the foremost common and deadly disease in the world. One of the most important cancer types is liver cancer and occurs either by being directly involved with liver cells resulting in primary liver cancers, ... -
Poli(Poliol)Sebakat Bazlı Biyobozunur Elastomerlerin Sentezi ve Jiro Eğrilmiş Fiber Destekli Hidrojel Doku İskelelerinin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2019)Poly(polyol) sebacate (PPS) based polymers are promising polymers in biomedical and tissue engineering field, thanks to tunable mechanical properties and having biodegradable and biocompatible features. However, difficult ... -
Karaciğer Tümörlerinin Tedavisinde Uygulanacak Y-90 Mikrokürelerin Aktivite Miktarlarının Hastaya Özgü Modelleme İle Belirlenmesi İçin Yöntem Geliştirilmesi ve Yöntemin Standardize Edilmesi
(Fen Bilimleri Enstitüsü, 2019)Yttrium-90 (Y-90) microsphere treatment is the internal radionuclide treatment through administration of Y-90 loaded microspheres to the tumor microcirculation via the relevant branch of the hepatic artery feeding the ... -
Selection and Validation of Aptamers Against Osteosarcoma By Cell-Selex Method
(Fen Bilimleri Enstitüsü, 2019)Osteosarcoma is known as the most common malignant mesenchymal stem cell development by endochondral ossification. Treatment resulting from an early diagnosis of such aggressive pediatric bone cancer can greatly increase ... -
Nerve Guidance Conduit Application Of Magnesium Alloys
(Fen Bilimleri Enstitüsü, 2019)Surgery is insufficient for peripheral nerve injuries larger than 5 mm. Function loss and scar formation occur as a result of slow healing rate and inflammation cells filling the damaged gap. Therefore, isolation of damaged ... -
Development Of Beta-Tricalcium Phosphate Based Injectable Synthetic Bone Graft Materials
(Fen Bilimleri Enstitüsü, 2018)As the global population ages, the number of patients suffering from bone tissue loss due to trauma, degenerative diseases, or surgical intervention increases. To meet the demand for bone graft materials, synthetic substitutes ... -
Dejeneratif Kıkırdak Hasarlarına Yönelik Enjekte Edilebilir Hidrojel Sistemlerinin Geliştirilmesi ve Karakterizasyonu
(Fen Bilimleri Enstitüsü, 2018)Cartilage degeneration is a pathology that develops over time, beginning with the softening of the cartilaginous gland and then completely disappearing. It may be due to trauma, as well as diseases such as osteoarthritis, ... -
Sklera Hasarlarının Rekonstruksiyonunda Otojenik, Allojenik Ve Zenojenik Greftlerin Karşılaştırılması: Yeni Bir Otolog Yaklaşım “Trombositten Zengin Fibrin Membran”
(Fen Bilimleri Enstitüsü, 2018)The purpose of the presented thesis was to compare the effects of xenogenic, allogenic and autogenic graft materials on scleral healing in the repair of scleral tissue damage. For this purpose, scleral tissue damage model ... -
Doku Mühendisliğinde Malzemeye Ve Hücresel Özelliklere Ait İmgelerin Görüntü İşleme Teknikleri İle Değerlendirilmesi
(Fen Bilimleri Enstitüsü, 2018)Image processing techniques are frequently used to obtain quantitative information from images of various imaging techniques. Image analysis in tissue engineering and cell biology is a time-consuming and specialized process. ... -
Kütle Spektrometrisi Uygulamalarında Fosfopeptitlerin Hassas Tayini İçin Yeni Stratejilerin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2018)Most of the proteins may at some time be phosphorylated on serine, threonine or tyrosine aminoacids when they perform a certain function. Phosphoprotein is protein that contain phosphate group in structure. The smaller ... -
Sferoid Yüklü Ecm-Mimetik Peptit Amfifil Hidrojellerle Çip-Üstü-Karaciğer Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2018-06-28)This study was financially supported by Hacettepe University Scientific Research Projects Coordination Unit with a project entitled “Development of the liver-on-chip to be used in determining the toxicity of drugs” (project ... -
Bor İçeren Nano Hidroksiapatit Kompozitlerin Kemik Hücrelerindeki Moleküler Etki Mekanizmasının Araştırılması
(Fen Bilimleri Enstitüsü, 2018)The structure of the bone and the self-renewal capacity are damaged by metabolic diseases and damages. The trace elements and hydroxyapatite crystals in the bone are important in the development of biomaterials to support ... -
Yüzeylerin Titanyum Nanoçubuklar Ve Onların Altın/Gümüş İle Modifiye Formları İle Nanodesenlenmesi Ve Farklı Alanlarda Kullanılabilirliklerinin İncelenmesi
(Fen Bilimleri Enstitüsü, 2018)Nanoscience and nanotechnology transform the material science into a wide range, providing the continuous development of new nanostructured materials. A comprehensive examination of physicochemical phenomena at the nanoscale ... -
Fenilketonüri Tanısı İçin Kağıt-Tabanlı Mikroakışkan Analitik Cihaz Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2018-10)Phenylketonuria (PKU), is a disease caused by the failure of phenylalanine metabolization and resulting accumulation at blood and other body fluids causing brain damage. Despite periodic phenylalanine monitoring is a ... -
Salinomisin ve BnHAp Yüklü Doku İskelelerinin Antikanserojen ve Antibakteriyel Etkinliğinin Araştırılması
(Fen Bilimleri Enstitüsü, 2018)In the scope of the thesis, it is aimed to investigate the synergistic effect of an anticancer drug, salinomycin, loaded poly (lactic-co-glycolic acid) (PLGA 65:35) nanoparticles with the boron doped nanohydroxyapatite ...
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