Kondanse 1,4-Dihidropiridin Türevlerinin Sentezi ile Antimikrobiyal ve Antioksidan Etkileri Üzerinde Çalışmalar
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BAYDAR, E. The Studies on Synthesis of Condensed 1,4-Dihydropyridine Derivatives and Their Antimicrobial and Antioxidant activities, Hacettepe University, Graduate School of Health Sciences, Master Thesis in Pharmaceutical Chemistry, Ankara, 2019. In this study twenty alkyl 2,6,6 (2,7,7)-trimethyl-4-(5/6-bromo-1H-indole-3-yl)-5-oxo-1,4,5,6,7,8-hexahydroqui- noline-3-carboxylate compounds (compound 1-20) have been synthesized. The structure of the compounds were elucidated by IR, 1H-NMR, 13C-NMR, mass spectroscopy and confirmed by elemental analyses. Additionally, the COSY spectrum of compound 7 and the X-ray spectrum of compound 3 were obtained. The antibacterial activities of the compounds against to Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus and the antifungal activities of the compounds to yeast-like fungi such as Candida albicans krusei, C. parapsilosis were determined by using liquid microdilution method in vitro. Their antimycobacterial activities were determined against Mycobacterium tuberculosis H37Rv in Middlebrook 7H11 agar medium in vitro. Molecular docking studies were realized using the complex of 1-cyclohexyl-N-(3,5-dichlorophenyl)-5-oxopirolidine-3-carboxamide with the published crystal structure of Mycobacterium tuberculosis enoil redüktaz enzyme (InhA). Antioxidant activity studies were realised by using Gamry Reference 600 model potentiostat/galvanostat system.