Cerrahi Tıp Bilimleri Bölümü

Targeting Plk1 Overcomes T-Dm1 Resistance Via Cdk1-Dependent Phosphorylation and Inactivation Of Bcl-2/Xl In Her2-Positive Breast Cancer

Saatçi, Özge; Borgoni, Simone; Akbulut, Özge; Durmuş, Selvi; Raza, Umar; Eyüpoğlu, Erol; Alkan, Can; Akyol, Aytekin; Kütük, Özgür; Wiemann, Stefan; Şahin, Özgür (Nature Publishing Group, 2018)

Trastuzumab-refractory, HER2 (human epidermal growth factor receptor 2)-positive breast cancer is commonly treated with trastuzumab emtansine (T-DM1), an antibody-drug conjugate of trastuzumab and the microtubule-targeting ...

Unsupervised Segmentation And Classification Of Cervical Cell Images

Gençtav, Aslı; Aksoy, Selim; Önder, Sevgen (Elsevier Sci Ltd, 2012)

The Pap smear test is a manual screening procedure that is used to detect precancerous changes in cervical cells based on color and shape properties of their nuclei and cytoplasms. Automating this procedure is still an ...

Analysis of Postural Stability and Daily Energy Expenditure to Manage Tumor Patients' Functional Expectation

Çalışkan, Emrah; Karadağ Saygı, Evrim; Gencer, Kardelen; Kurtel, Hızır; Erol, Bülent (The Korean Orthopaedic Association, 2018)

Background Advances in surgical techniques, implant technology, radiotherapy, and chemotherapy have increased the recovery chances of patients with bone sarcomas. Accordingly, patients' expectations on life quality have ...

Age-Stratified Analysis Of Tumor Markers And Tumor Characteristics In Adolescents And Young Women With Mature Cystic Teratoma

Yeşilyurt, Hüseyin; Seçkin, Berna; Aktulay, Ayla; Özyer, Şebnem (Elsevier Taiwan, 2018)

Background: Serum tumor markers are widely used for the preoperative evaluation of an adnexal mass. Elevations of cancer antigen (CA) 125 and CA 19-9 have been reported in patients with mature cystic teratoma (MCT). The ...

Effect Of Stem Cell Application On Asherman Syndrome, An Experimental Rat Model

Kılıç, Sevtap; Yüksel, Beril; Alparslan Pınarlı, Ferda; Albayrak, A.; Boztok Özgermen, Başak; Delibaşı, Tuncay (Springer/Plenum Publishers, 2014)

We evaluate the effect of stem cells to induce endometrial proliferation and angiogenesis on Asherman Syndrome (AS). The experimental study was performed in stemcell research laboratory. Forty Wistar-Albino rats were divided ...

EVAPORATİF KURU GÖZ HASTALIĞI OLUŞUMUNDA MEİBOMİUS BEZ HASTALIĞININ VE NÖROMEDİYATÖRLERİN ROLÜ

Bilgiç, Ahmet Alp; Bilgiç, Ahmet Alp (Tıp Fakültesi, 2019)

The aim of this study is to evaluate the effects of visual display terminal (VDT) work and meibomian gland dysfunction (MGD) on the ocular surface and their association with dry eye disease. In addition, the comparison of ...

Kolonik Subepitelyal ve Perikriptal Myofibroblastlar İçin İmmunohistokimyasal Belirteçlerin Tanımlanması ve Neoplastik Süreçteki İfadelerinin Araştırılması

Katipoğlu, Kübra (Tıp Fakültesi, 2019)

Colonic subepithelial and pericryptal myofibroblasts are located just beneath the epithelium in the colonic lamina propria whom are -SMA positive mesenchymal cells that play a role in many processes such as wound healing, ...

Myelomeningosel Skolyozunda Posterior Enstrümantasyon ve Füzyon: Ardışık İki ve Daha Fazla Lamina Defekti Olan Eğriliklerde Posterior Enstrümantasyon ve Füzyon Cerrahisi Sonuçlarının Değerlendirilmesi

Şahin, Buğrahan (Tıp Fakültesi, 2019)

Buğrahan Şahin, Posterior instrumentation and fusion in myelomeningocele scoliosis: Evaluation of posterior instrumentation and fusion surgery results in spinal curves with two or more consecutive lamina defects, Hacettepe ...

SIÇAN SPİNAL KORD HASARI MODELİNDE İZOALANTOLAKTON’UN NÖROİNFLAMASYON ÜZERİNE ETKİLERİNİN İNCELENMESİ

Tarazi, Basel (Tıp Fakültesi, 2019)

Introduction & Objectives: Spinal cord injury (SCI) is a complex and destructive condition that affects many body functions. After the spinal cord trauma, the production of free oxygen radicals in the first 24 hours following ...

ANTİFOSFOLİPİD, ANTİKARDİYOLİPİN, EKSTRAKTE EDİLEBİLEN NÜKLEER ANTİJEN VE ANTİ-ÇİFT SARMAL DNA ANTİKORLARININ POZİTİF OLMASININ GEBELİK SONUÇLARI ÜZERİNE ETKİSİ

Tanacan, Atakan (Tıp Fakültesi, 2019)

Tanacan A, Impact of Extractable Nuclear Antigen, Anti-Double Stranded DNA, Antiphospholipid Antibody, and Anticardiolipin Antibody Positivity on Obstetrical Complications and Pregnancy Outcomes, Hacettepe University Faculty ...

LİTOTOMİ POZİSYONUNDA AÇIK ABDOMİNAL CERRAHİ GEÇİRECEK HASTALARDA ISITMA SİSTEMLERİNİN ETKİNLİĞİNİN KARŞILAŞTIRILMASI

ÖZDEMİR YAŞAR, Pınar (Tıp Fakültesi, 2019)

Inadvertent perioperative hypothermia is a significant complication observed during anesthesia and surgery. The patients undergoing open abdominal surgery at lithotomy position is a major risk group for hypothermia. ...

OPERE EDİLMİŞ OLAN KONJENİTAL/İNFANTİL KATARAKT HASTALARINDA KLİNİK ÖZELLİKLER, ZAMAN İÇERİSİNDE OKÜLER PARAMETRELERİN DEĞİŞİMİ, OKÜLER ERKEN VE GEÇ DÖNEM KOMPLİKASYONLARININ GELİŞMESİNDE KLİNİK RİSK FAKTÖRLERİNİN BELİRLENMESİ

Sögüt, Pelin (Tıp Fakültesi, 2019-08)

The aim of this study was to determine the change of ocular parameters, early and late complications, their relationship with clinical features and preoperative risk factors in unilateral/bilateral congenital/infantile ...

Akut Periferik Sinir Yaralanmalarının Rejenerasyonunda Epidermal Büyüme Faktörü (EGF)’nün Etkilerinin Tavşan Modeli Üzerinde Histolojik İncelenmesi

Ayık, Gökhan (Tıp Fakültesi, 2019-08-19)

Peripheral nerve injuries are one of the most common and costly injuries especially in the young population. In this study, it is aimed to determine the histological role of EGF in nerve regeneration with a damage made on ...

Eklem Kıkırdak Defektlerine Hücreden Arındırılmış İnsan Plasentası, Mezenkimal Kök Hücre ve PRP Kombinasyonlarının Uygulanması ile Histolojik İyileşmenin Değerlendirilmesi - Sıçan Modeli

Özdemir, Erdi (Tıp Fakültesi, 2019-08-19)

The articular cartilage is of a hyaline cartilage structure and the healing capacity is very poor when it is damaged. Although an optimal treatment method has not been defined, tissue engineering studies are promising in ...

RENAL KİTLE DEĞERLENDİRİLMESİNDE TC-99M MİBİ TÜMÖR SİNTİGRAFİSİNİN ROLÜ: GERÇEK FAYDA VAR MI?

Asi, Tariq Jamal Abdel-Jaber (Sağlık Bilimleri Enstitüsü, 2019-08-08)

Objective: The role of Tc-99m methoxy isobutyl-isonitrile (MİBİ) tumor scintigraphy in the differentiation of benign and malignant renal masses is still controversial. We sought to demonstrate the efficacy of Tc-99m MİBİ ...

Böbrek Kitleleri Nedeniyle Parsiyel Nefrektomi Yapılan Hastalarda Nefrometri Skorlarının İntraoperatif ve Postoperatif Sonuçları Öngörmedeki Yeri

Haberal, Hakan Bahadır (Tıp Fakültesi, 2019)

Nephrometry scores of 162 partial nephrectomy patients with the diagnosis of renal tumor between 2012 and 2017 were retrospectively analyzed. The prediction value of nephrometry scores on intraoperative and postoperative ...

KRONİK OTİTİS MEDİALI HASTALARDA CERRAHİ ÖNCESİ TEMPORAL KEMİK BİLGİSAYRLI TOMOGRAFİ BULGULARI İLE İNTRAOPERATİF BULGULARIN KARŞILAŞTIRILMASI

Habibullah, Habib (Tıp Fakültesi, 2019-06-19)

Habib H. The correlation of Preoperative Temporal Bone Computed Tomography Findings with Intraoperative Findings In Chronic Otitis Media Patients. Hacettepe University Faculty Of Medicine ENT Department, Speciality Thesis, ...