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High Prevalence Of Tert Promoter Mutations In Micropapillary Urothelial Carcinoma

Nguyen, Doreen; Taheri, Diana; Springer, Simeon; Cowan, Morgan; Guner, Gunes; Rodriguez, Maria Angelica Mendoza; Wang, Yuxuan; Kinde, Isaac; VandenBussche, Christopher J.; Olson, Matthew T.; Ricardo, Bernardo F. P.; Cunha, Isabela; Fujita, Kazutoshi; Ertoy, Dilek; Kinzler, Kenneth W.; Bivalacqua, Trinity J.; Papadopoulos, Nickolas; Vogelstein, Bert; Netto, George J. (Springer, 2016)

Somatic activating mutations in the promoter of the telomerase reverse transcriptase (TERT) gene are the most common genetic alterations in urothelial carcinoma (UC) of the bladder and upper urinary tract. Little is known, ...

High Prevalence Of Tert Promoter Mutations In Primary Squamous Cell Carcinoma Of The Urinary Bladder

Cowan, Morgan; Springer, Simeon; Nguyen, Doreen; Taheri, Diana; Guner, Gunes; Rodriguez, Maria Angelica Mendoza; Wang, Yuxuan; Kinde, Isaac; VandenBussche, Christopher J.; Olson, Matthew T.; Cunha, Isabela; Fujita, Kazutoshi; Ertoy, Dilek; Bivalacqua, Trinity J.; Kinzler, Kenneth; Vogelstein, Bert; Netto, George J.; Papadopoulos, Nickolas (Nature Publishing Group, 2016)

TERT promoter mutations (TERT-mut) are detectable in the majority of urothelial carcinomas. The detection of TERT-mut in urine is under investigation as a potential urine-based molecular-screening assay for bladder cancer. ...

Tle1 Expression Is Not Specific For Synovial Sarcoma: A Whole Section Study Of 163 Soft Tissue And Bone Neoplasms

Kosemehmetoglu, Kemal; Vrana, Julie A.; Folpe, Andrew L. (Nature Publishing Group, 2009)

TLE1, a transcriptional repressor essential in hematopoiesis, neuronal differentiation and terminal epithelial differentiation, has recently been shown in a single tissue microarray study to be a highly sensitive and ...

Immunohistochemical Investigation Of Endometrial Leukocytes In Implantation Period In Rats With Streptozotosin-Induced Diabetes

Nacar, Emel; Bozkurt, Yesim Akaydin; Koc, Ahmet; Nacar, Ahmet (Vesalius Univ Medical Publ, 2016)

Our first aim was to determine the total leukocyte profile in implantation. Second aim was to detect the changes in uterine leukocyte profile in diabetes, a common accompanying disease. For this purpose 4 groups are formed ...

Serous Versus High-Grade Endometrioid Endometrial Carcinoma: Immunohistochemistry of Rfp Is Not Useful For Differentiation

Ussaklı, Ciğdem; Usubütün, Alp; Dinçer, Nazmiye; Dolgun, Anıl; Bülbül, Dilek; Isıkdoğan, Zuhal; Haberal, Nihan; Özen, Özlem; Tezel, Gaye Guler (Vesalius Univ Medical Publ, 2016)

We evaluated the immunohistochemical expression of ret finger protein (RFP) along with conventional immunohistochemical markers in endometrioid and serous carcinomas of the endometrium. A total of 124 endometrial carcinoma ...

Microscopic And Electrophysiological Changes On Regenerating Sciatic Nerves Of Rats Treated With Simvastatin

Daglioglu, Ergun; Berker, Mustafa; Demirci, Mehmet; Tuncel, Muervet; Karabulut, Erdem; Erbengi, Aykut (Via Medica, 2010)

Simvastatin is a hypocholesterolemic agent presumed to cause peripheral neuropathy. We arranged an experimental design which focuses on the effect of simvastatin on peripheral nerves and neural regeneration. Sciatic nerve ...

Pax-2 in the Diagnosis of Primary Renal Tumors Immunohistochemical Comparison with Renal Cell Carcinoma Marker Antigen and Kidney-Specific Cadherin

Ozcan, Ayhan; Zhai, Jim; Hamilton, Candice; Shen, Steven S.; Ro, Jae Y.; Krishnan, Bhuvaneswari; Truong, Luan D. (Amer Soc Clinical Pathology, 2009)

The diagnosis of renal cell carcinoma (RCC) remains problematic, especially in the context of metastasis or small needle biopsy specimens. The renal cell carcinoma marker (RCCM) and kidney-specific cadherin (KSC) are ...

Metastasis Suppressor Proteins In Cutaneous Squamous Cell Carcinoma

Bozdogan, Onder; Vargel, Ibrahim; Cavusoglu, Tarik; Karabulut, Ayse A.; Karahan, Gurbet; Sayar, Nilufer; Atasoy, Pinar; Yulug, Isik G. (Elsevier Gmbh, Urban & Fischer Verlag, 2016)

Cutaneous squamous cell carcinomas (cSCCs) are common human carcinomas. Despite having metastasizing capacities, they usually show less aggressive progression compared to squamous cell carcinoma (SCC) of other organs. ...

An Unusual Case Of Invasive Papillary Carcinoma Of The Breast

Terzi, Aysen; Uner, Aysegul Hasegeli (Medknow Publications & Media Pvt Ltd, 2012)

Invasive papillary carcinoma is a rare variant of breast cancer. We report an unusual case of invasive papillary carcinoma of the breast with high nuclear grade, brisk mitosis, necrosis, extensive apocrine differentiation, ...

Detection Of Tert Promoter Mutations In Primary Adenocarcinoma Of The Urinary Bladder

Cowan, Morgan L.; Springer, Simeon; Nguyen, Doreen; Taheri, Diana; Guner, Gunes; Rodriguez, Maria Angelica Mendoza; Wang, Yuxuan; Kinde, Isaac; Pena, Maria Del Carmen Rodriguez; VandenBussche, Christopher J.; Olson, Mathew T.; Cunha, Isabela; Fujita, Kazutoshi; Ertoy, Dilek; Kinzler, Kenneth; Bivalacqua, Trinity; Papadopoulos, Nickolas; Vogelstein, Bert; Netto, George J. (W B Saunders Co-Elsevier Inc, 2016)

TERT promoter mutations (TERT-mut) have been detected in 60% to 80% of urothelial carcinomas. A molecular urine-based screening assay for the detection of TERT-mut is currently being pursued by our group and others. A small ...