dc.contributor.author | Kahraman, S | |
dc.contributor.author | Ercan, S | |
dc.contributor.author | Aypar, U | |
dc.contributor.author | Erdem, K | |
dc.date.accessioned | 2019-12-12T06:40:45Z | |
dc.date.available | 2019-12-12T06:40:45Z | |
dc.date.issued | 1993 | |
dc.identifier.issn | 0007-0912 | |
dc.identifier.uri | https://doi.org/10.1093/bja/71.2.238 | |
dc.identifier.uri | http://hdl.handle.net/11655/16602 | |
dc.description.abstract | We have studied the effects of preoperative administration of diclofenac on suxamethonium-induced myalgia, plasma met-enkephalin-like activity (E-LA), prostaglandin E2-like activity (PGE2-LA), leukotriene C4-like activity (LTC4-LA) and histamine-like activity (H-LA). Thirty-four ASA I patients undergoing elective ophthalmic surgery were allocated randomly to two groups to receive either saline placebo or diclofenac 75 mg i.m. 20 min before operation, in a double-blind design. Anaesthesia was induced with thiopentone 5-7 mg kg-1 followed by suxamethonium 1. 5 mg kg-1 and maintained with 67% nitrous oxide and halothane in oxygen. Plasma PGE2-LA, LTC4-LA, H-LA and E-LA were measured before premedication, 1 min after the administration of suxamethonium and 24 h after operation. Muscle fasciculations, intubation conditions and postoperative myalgia were graded numerically. Postoperative myalgia in the diclofenac group was significantly (P < 0.05) less (47.1%) than in the control gro up (76.5%). Post-suxamethonium and 24-h concentrations of plasma PGE2-LA and LTC4-LA were also significantly (P < 0.05) greater than baseline in the control group. Plasma H-LA was increased in both groups after suxamethonium and this increase was significant (P < 0.05) in the control group. We conclude that diclofenac reduces significantly the incidence and intensity of suxamethonium-induced myalgia. | |
dc.language.iso | en | |
dc.publisher | Elsevier Sci Ltd | |
dc.relation.isversionof | 10.1093/bja/71.2.238 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Anesthesiology | |
dc.title | Effect of Preoperative I. M. Administration of Diclofenac on Suxamethonium-Induced Myalgia | |
dc.type | info:eu-repo/semantics/article | |
dc.relation.journal | British Journal Of Anaesthesia | |
dc.contributor.department | Anesteziyoloji ve Reanimasyon | |
dc.identifier.volume | 71 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 238 | |
dc.identifier.endpage | 241 | |
dc.description.index | WoS | |
dc.description.index | Scopus | |