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dc.contributor.authorKahraman, S
dc.contributor.authorErcan, S
dc.contributor.authorAypar, U
dc.contributor.authorErdem, K
dc.date.accessioned2019-12-12T06:40:45Z
dc.date.available2019-12-12T06:40:45Z
dc.date.issued1993
dc.identifier.issn0007-0912
dc.identifier.urihttps://doi.org/10.1093/bja/71.2.238
dc.identifier.urihttp://hdl.handle.net/11655/16602
dc.description.abstractWe have studied the effects of preoperative administration of diclofenac on suxamethonium-induced myalgia, plasma met-enkephalin-like activity (E-LA), prostaglandin E2-like activity (PGE2-LA), leukotriene C4-like activity (LTC4-LA) and histamine-like activity (H-LA). Thirty-four ASA I patients undergoing elective ophthalmic surgery were allocated randomly to two groups to receive either saline placebo or diclofenac 75 mg i.m. 20 min before operation, in a double-blind design. Anaesthesia was induced with thiopentone 5-7 mg kg-1 followed by suxamethonium 1. 5 mg kg-1 and maintained with 67% nitrous oxide and halothane in oxygen. Plasma PGE2-LA, LTC4-LA, H-LA and E-LA were measured before premedication, 1 min after the administration of suxamethonium and 24 h after operation. Muscle fasciculations, intubation conditions and postoperative myalgia were graded numerically. Postoperative myalgia in the diclofenac group was significantly (P < 0.05) less (47.1%) than in the control gro up (76.5%). Post-suxamethonium and 24-h concentrations of plasma PGE2-LA and LTC4-LA were also significantly (P < 0.05) greater than baseline in the control group. Plasma H-LA was increased in both groups after suxamethonium and this increase was significant (P < 0.05) in the control group. We conclude that diclofenac reduces significantly the incidence and intensity of suxamethonium-induced myalgia.
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.isversionof10.1093/bja/71.2.238
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnesthesiology
dc.titleEffect of Preoperative I. M. Administration of Diclofenac on Suxamethonium-Induced Myalgia
dc.typeinfo:eu-repo/semantics/article
dc.relation.journalBritish Journal Of Anaesthesia
dc.contributor.departmentAnesteziyoloji ve Reanimasyon
dc.identifier.volume71
dc.identifier.issue2
dc.identifier.startpage238
dc.identifier.endpage241
dc.description.indexWoS
dc.description.indexScopus


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