3,7-Dimethylguanine, A New Purine From A Philippine Sponge Zyzzya Fuliginosa
Mangalindan, Gina C
Concepcion, Gisela P
Harper, Mary Kay
Irelanda, Chris M
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A new purine 3,7-dimethylguanine (1) has been isolated from the marine sponge Zyzzya fuliginosa, along with the known metabolites. makaluvamines A, C, K (2-4), 4-hydroxyphenylacetic acid (5), methyl ester of 4-hydroxyphenylacetic acid (6), 4-hydroxyphenethyl alcohol (7), L-phenylalanine (8) and L-tryptophan (9). The structure of 3,7-dimethylguanine (1) was elucidated by analysis of 1D and 2D (one- and two-dimensional) NMR [HMQC (heteronuclear multiple quantum coherence), gHMBC (heteronuclear multiple bond connectivity), H-1-N-15 gHMBC] data, mass spectroscopy data, and by comparison with 3,7-dimethylisoguanine (10).