• Türkçe
    • English
  • English 
    • Türkçe
    • English
  • Login
View Item 
  •   DSpace Home
  • Eczacılık Fakültesi
  • Temel Eczacılık Bilimleri Bölümü
  • Temel Eczacılık Bilimleri Bölümü Makale Koleksiyonu
  • View Item
  •   DSpace Home
  • Eczacılık Fakültesi
  • Temel Eczacılık Bilimleri Bölümü
  • Temel Eczacılık Bilimleri Bölümü Makale Koleksiyonu
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

In Vivo And In Vitro Effects Of A Hif-1 Alpha Inhibitor, Rx-0047

View/Open
licence.txt (265bytes)
3360.pdf (267.5Kb)
Date
2008
Author
Dikmen, Z. Gunnur
Gellert, Ginelle C.
Dogan, Palkize
Yoon, Heejeong
Lee, Young Bok
Ahn, Chang Ho
Shay, Jerry W.
xmlui.mirage2.itemSummaryView.MetaData
Show full item record
Abstract
HIF-1 alpha plays a major role in activating gene transcription and is important for maintaining homeostasis under hypoxic conditions. Since tumors are often in a hypoxic state, HIF-1 alpha is a potential target for the development of novel cancer therapeutics. This study was performed to determine the antitumoral efficacy of an antisense HIF-1 alpha inhibitor, RX-0047 on different human cancer cell lines (MDA-MB 231, HME50-T, PC-3, Panc-1 and A549) in vitro. A549 lung cancer and PC-3 prostate cancer cells containing a luciferase gene reporter were used for in vivo xenograft animal models. Progressive tumor development was quantified using live animal BLI (bioluminescence imaging) in addition to ex vivo imaging and histology. All cell lines tested were sensitive to inhibition of cell growth with 10 nM and higher ranges of RX-0047, additionally RX-0047 sensitizes cells to ionizing radiation treatments. Finally, RX-0047 (30 mg/kg) inhibited the formation of human lung metastasis in xenograft mouse models and reduced tumor size in flank models.
URI
https://doi.org/10.1002/jcb.21681
http://hdl.handle.net/11655/20107
xmlui.mirage2.itemSummaryView.Collections
  • Temel Eczacılık Bilimleri Bölümü Makale Koleksiyonu [123]
Hacettepe Üniversitesi Kütüphaneleri
Açık Erişim Birimi
Beytepe Kütüphanesi | Tel: (90 - 312) 297 6585-117 || Sağlık Bilimleri Kütüphanesi | Tel: (90 - 312) 305 1067
Bizi Takip Edebilirsiniz: Facebook | Twitter | Youtube | Instagram
Web sayfası:www.library.hacettepe.edu.tr | E-posta:openaccess@hacettepe.edu.tr
Sayfanın çıktısını almak için lütfen tıklayınız.
Contact Us | Send Feedback



DSpace software copyright © 2002-2016  DuraSpace
Theme by 
Atmire NV
 

 


DSpace@Hacettepe
huk openaire onayı
by OpenAIRE

About HUAES
Open Access PolicyGuidesSubcriptionsContact

livechat

sherpa/romeo

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsTypeDepartmentPublisherLanguageRightsxmlui.ArtifactBrowser.Navigation.browse_indexFundingxmlui.ArtifactBrowser.Navigation.browse_subtypeThis CollectionBy Issue DateAuthorsTitlesSubjectsTypeDepartmentPublisherLanguageRightsxmlui.ArtifactBrowser.Navigation.browse_indexFundingxmlui.ArtifactBrowser.Navigation.browse_subtype

My Account

LoginRegister

Statistics

View Usage Statistics

DSpace software copyright © 2002-2016  DuraSpace
Theme by 
Atmire NV