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dc.contributor.authorSirin, Fevziye Burcu
dc.contributor.authorDoguc, Duygu Kumbul
dc.contributor.authorVural, Huseyin
dc.contributor.authorEren, Ibrahim
dc.contributor.authorInanli, Ikbal
dc.contributor.authorSutcu, Recep
dc.contributor.authorDelibas, Namik
dc.date.accessioned2019-12-16T10:29:32Z
dc.date.available2019-12-16T10:29:32Z
dc.date.issued2015
dc.identifier.issn1300-0144
dc.identifier.urihttps://doi.org/10.3906/sag-1406-134
dc.identifier.urihttp://hdl.handle.net/11655/20136
dc.description.abstractBackground/aim: F2 alpha-isoprostane is accepted as an oxidative stress indicator and melatonin shows neuroprotective effects by antioxidative and antiamyloidogenic influences. By measuring these in patients diagnosed with minimal cognitive impairment (MCI) and Alzheimer-type dementia, we intended to demonstrate whether the measurement of these markers contributes to early diagnosis of Alzheimer disease (AD) in the MCI stage or not. Materials and methods: Three groups (n = 63) were created: the AD group, MCI group, and control group. Serum melatonin levels were measured by radioimmunoassay method, and plasma total 8-isoPGF2 alpha levels were measured by enzyme immunoassay method. Results: Significant differences were observed in the melatonin levels between the MCI group and AD group (P = 0.009), and in 8-isoPGF2 alpha levels between the AD group and control group (P = 0.022). A negative correlation between mini-mental state examination (MMSE) scores and 8-isoPGF2 alpha levels (r = -0.459, P < 0.001) and positive correlation between MMSE scores and melatonin levels (r = 0.317, P = 0.011) were found. Conclusion: Although the plasma 8-isoPGF2 alpha and serum melatonin levels in MCI were not found to be good early diagnostic markers to indicate risk of AD, results were found to support the role of oxidative stress in AD.
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.isversionof10.3906/sag-1406-134
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGeneral & Internal Medicine
dc.titlePlasma 8-Isopgf2 Alpha and Serum Melatonin Levels in Patients with Minimal Cognitive Impairment and Alzheimer Disease
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalTurkish Journal Of Medical Sciences
dc.contributor.departmentBiyokimya
dc.identifier.volume45
dc.identifier.issue5
dc.identifier.startpage1073
dc.identifier.endpage1077
dc.description.indexWoS
dc.description.indexScopus


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