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Bmprii Deficiency Impairs Apoptosis Via The Bmprii-Alk1-Bclx-Mediated Pathway In Pulmonary Arterial Hypertension
(2019)Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder characterized by the remodelling of pre-capillary pulmonary arteries. The vascular remodelling observed in PAH patients results from excessive ... -
Capecitabine Induced Hand-Foot Syndrome: A Systematic Review Of Case Reports
(2019)Objective: Capecitabine, a prodrug of 5-fluorouracil, is currently used in the treatment of metastatic colorectal and breast cancers. The aim of this study was to review the pharmacological mechanisms, treatment strategies, ... -
Cardenolide Production As An Important Drug Agent
(Bentham Science Publ, 2012)Leaves of Digitalis plants are still the major source for the isolation of cardenolides, especially digitoxin and digoxin that are used to treat cardiac insufficiency in humans. Cardenolides are characterized by a steroid ... -
Characterization Of Volatile Compounds Of Eleven Achillea Species From Turkey And Biological Activities Of Essential Oil And Methanol Extract Of A. Hamzaoglui Arabacı & Budak
(2015)According to distribution of genus Achillea, two main centers of diversity occur in S.E. Europe and S.W. Asia. Diversified essential oil compositions from Balkan Peninsula have been numerously reported. However, report on ... -
Chemical Composition, Antioxidant And Anticholinesterase Activities Of The Essential Oil Of Origanum Rotundifolium Boiss. From Turkey
(Acg Publications, 2017)The essential oil was obtained by hydrodistillation from the aerial parts of Origanum rotundifolium Boiss. Its chemical content and composition were analyzed by using a gas chromatography (GC-FID) and gas chromatography-mass ... -
Chemical Composition, Antioxidant Capacity, Acetyl- And Butyrylcholinesterase Inhibitory Activities Of The Essential Oil Of Thymus Haussknechtii Velen.
(Acg Publications, 2016)The chemical composition of the essential oil from the aerial parts of Thymus haussknechtii Velen. was analyzed by using gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The major component of ... -
Chemical Compositions And Antimicrobial Activities Of Four Different Anatolian Propolis Samples
(Elsevier Gmbh, Urban & Fischer Verlag, 2005)Propolis means a gum that is gathered by bees from various plants. It is known for its biological properties, having antibacterial, antifungal and heating properties. The aims of this study were to evaluate the antimicrobial ... -
Cholinesterase Inhibition And Molecular Docking Studies Of Sesquiterpene Coumarin Ethers From Heptaptera Cilicica
(Acg Publications, 2017)Five sesquiterpene coumarin ethers: umbelliprenin, umbelliprenin-10', 11'-monoepoxide, conferone, mogoltacin and feselol were isolated from the fruits of Heptaptera cilicica. Their structures were identified by means of ... -
Comparative Studies On Phenolic Composition, Antioxidant, Wound Healing And Cytotoxic Activities Of Selected Achillea L. Species Growing In Turkey
(2015)Turkey is one of the most important centers of diversity for the genus Achillea L. in the world. Keeping in mind the immense medicinal importance of phenols, in this study, three species growing in Turkey, A. coarctata ... -
Comparison Of Antioxidant Activities Of Aminoguanidine, Methylguanidine And Guanidine By Luminol-Enhanced Chemiluminescence
(Wiley, 1998)1 The objective of this study was to investigate the ability of aminoguanidine, methylguanidine and guanidine to inhibit free radicals or metabolites generated by either stimulated human leucocytes or cell-free systems ... -
Crypthophilic Acids A, B, And C: Resin Glycosides From Aerial Parts Of Scrophularia Crypthophila
(Amer Chemical Soc, 2007)The water-soluble part of the methanolic extract from the aerial parts of Scrophularia crypthophila, through chromatographic methods, yielded three new resin glycosides, crypthophilic acids A-C (1-3). Compounds 1-3 are ... -
Cuscuta Arvensis Beyr “Dodder”: In Vivo Hepatoprotective Effects Against Acetaminophen-Induced Hepatotoxicity In Rats
(2018)Cuscuta arvensis Beyr. is a parasitic plant, and commonly known as “dodder” in Europe, in the United States, and “tu si zi shu” in China. It is one of the preferred spices used in sweet and savory dishes. Also, it is used ... -
Cyp2C19 Genotype Does Not Represent A Genetic Predisposition In Idiopathic Systemic Lupus Erythematosus
(British Med Journal Publ Group, 1999)Background-The aetiology of systemic lupus erythematosus (SLE) is still unknown. In several cases, however, chemicals or drugs were identified as aetiological agents and associations with certain phenotypes of drug ... -
Design, Synthesis And In Vivo/In Vitro Screening Of Novel Chlorokojic Acid Derivatives
(Taylor & Francis Ltd, 2013)A series of novel Mannich bases of chlorokojic acid (2-chloromethyl-5-hydroxy-4H-pyran-4-one) were synthesized and their biological activities were investigated. Anticonvulsant activity results according to phase-I tests ... -
Detection Of Neopterin In Tear Samples
(Walter De Gruyter Gmbh, 2016)The main goal of the present study was to detect neopterin concentrations in human tear samples and to evaluate its potential correlation with serum neopterin levels. For this purpose, 20 systemically healthy volunteers ... -
Direct Enantiomeric Resolution Of Seventeen Racemic 1,4-Dihydropyridine-Based Hexahydroquinoline Derivatives By Hplc
(2019)1,4-Dihydropyridine (DHP) scaffold holds an outstanding position with its versatile pharmacological properties among all heterocyclic compounds. Although most of the commercially available DHPs are marketed as a racemic ... -
Discovery And Characterisation Of Dual Inhibitors Of Tryptophan 2,3-Dioxygenase (Tdo2) And Indoleamine 2,3-Dioxygenase 1 (Ido1) Using Virtual Screening
(2019)Cancers express tryptophan catabolising enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2) to produce immunosuppressive tryptophan metabolites that undermine patients’ immune systems, leading ... -
Effects Of Cinnamic Acid On Complications Of Diabetes
(Tubitak Scientific & Technical Research Council Turkey, 2018)Background/aim: Diabetes mellitus (DM) is a major health problem worldwide. Cinnamic acid (CA) and its derivatives are synthesized in plants and increasing attention has been given to them in recent years due to the high ... -
Effects Of Developmental Exposure To Silver In Ionic And Nanoparticle Form: A Study In Rats
(2016)Background Evaluations of silver in both nanoparticle (Ag-NPs) and ionic forms indicate some adverse effects on living organisms, but little is known about their potential for developmental toxicity. In this study, ...
