Recent Submissions
-
Evaluation Of Some Biological Effects Of Incarvillea Emodi (Royle Ex Lindl.) Chatterjee And Determination Of Its Active Constituents
(2019)This present study was an evaluation of the antioxidant and cytotoxic activities of Incarvillea emodi (Bignoniaceae). The aqueous extracts of different parts of Incarvillea emodi, collected from different places in Pakistan, ... -
Molecular Modeling-Based Delivery System Enhances Everolimus-Induced Apoptosis In Caco-2 Cells
(2019), Several studies have shown that the mammalian target of rapamycin (mTOR) inhibitor; everolimus (EV) improves patient survival in several types of cancer. However, the meaningful efficacy of EV as a single agent for the ... -
Phytochemical Screening And Evaluation Of The Antimicrobial And Antioxidant Activities Of Ferula Caspica M. Bieb. Extracts
(2019)Chloroform, ethyl acetate and methanol extracts from the aerial parts of Ferula caspica M. Bieb. were tested for their antioxidant capacities by CUPRAC, ABTS, FRAP, Folin–Ciocalteu and aluminum chloride methods and for ... -
Reishimax Inhibits Mtorc1/2 By Activating Ampk And Inhibiting Igfr/Pi3K/Rheb In Tumor Cells
(2019)Ganoderma lucidum (G. lucidum) extracts, as dietary supplements, have been found to exert potent anticancer activity, which is attributed to the presence of polysaccharides and triterpenes. However, the molecular mechanism ... -
Bmprii Deficiency Impairs Apoptosis Via The Bmprii-Alk1-Bclx-Mediated Pathway In Pulmonary Arterial Hypertension
(2019)Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder characterized by the remodelling of pre-capillary pulmonary arteries. The vascular remodelling observed in PAH patients results from excessive ... -
Polypharmacy And Drug-Related Problems Among People Living With Hiv/Aids: A Single-Center Experience
(2019)Background/aim: The HIV-infected population is aging, and the concomitant comorbidities increase the likelihood of polypharmacy. There is a scarcity of data for determining drug-related problems in people living with ... -
Capecitabine Induced Hand-Foot Syndrome: A Systematic Review Of Case Reports
(2019)Objective: Capecitabine, a prodrug of 5-fluorouracil, is currently used in the treatment of metastatic colorectal and breast cancers. The aim of this study was to review the pharmacological mechanisms, treatment strategies, ... -
Alpha-Pyrone Glycosides From Scutellaria Salviifolia Benth
(2019)Scutellaria salviifolia Benth. is an endemic species growing in Turkey that belongs to the family Lamiaceae. As a result of a phytochemical study on the aerial parts of S. salviifolia Benth., two new and 10 known compounds ... -
Acetylcholinesterase Inhibitory Activities And Lc-Ms Analysis Of The Antioxidant Ferula Caspica M. Bieb. And F. Halophila Pesmen Extracts
(2019)The aim of the current study is to evaluate the biological activity of F. caspica M. Bieb. which is used for the treatment of diabetes in traditional Turkish medicine and to compare with F. halophila Pesmen. Antioxidant ... -
Neopterin Levels And Indoleamine 2,3-Dioxygenase Activity As Biomarkers Of Immune System Activation And Childhood Allergic Diseases
(2019)Background Although Th2 immune activation is predominant in allergic diseases, neopterinlevels and indoleamine 2,3-dioxygenase (IDO)-1 activity (kynurenine:tryptophan ratio), which reflect Th1 immune activity, increase ... -
An In Vitro Study On The Cytotoxicity And Genotoxicity Of Silver Sulfide Quantum Dots Coated With Meso-2,3-Dimercaptosuccinic Acid
(2019)Objectives: Silver sulfide (Ag2S) quantum dots (QDs) are highly promising nanomaterials in bioimaging systems due to their high activities for both imaging and drug/gene delivery. There is insufficient research on the ... -
Epigenetic And Genetic Changes Caused By Helicobacter Pylori And Their Roles In Gastric Carcinogenesis
(2019)Objective: Helicobacter pylori is a bacteria which colonizes in the gastric mucosa and it is one of the major infectious diseases throughout the world. There are findings pointing out that Helicobacter pylori can cause ... -
Mycotoxin Detection In Maize, Commercial Feed, And Raw Dairy Milk Samples From Assiut City, Egypt
(2019)This survey was conducted to investigate the contamination by multiple mycotoxins, aflatoxins (AFB1, AFB2, AFG1, and AFG2), ochratoxin A (OTA), and zearalenone (ZEA) in 61 samples of maize and 17 commercial animal feed ... -
In Vitro Investigation Of The Effects Of Boron Nitride Nanotubes And Curcumin On Dna Damage
(2019)Backround Stem cells provide an opportunity to analyse the effects of xenobiotic on cell viability, differentiation and cell functions. Evaluation of the possible cytotoxic and DNA damaging effects on bone marrow CD34+ ... -
Antioxidants And Selenocompounds Inhibit 3,5-Dimethylaminophenol Toxicity To Human Urothelial Cells
(2019)Exposure to alkyl anilines may lead to bladder cancer, which is the second most frequent cancer of the urogenital tract. 3,5-dimethylaniline is highly used in industry. Studies on its primary' metabolite 3,5-dimethylaminophenol ... -
An Exploratory Study Of Neopterin And Kynurenine Pathway In Pterygium
(2019)Pterygium is an inflammatory, vascular and degenerative disorder with unknown aetiology. The aim of this study was to evaluate the changes in neopterin levels, reflecting T-cell immunity, and the kynurenine pathway, the ... -
A New Perspective On Evaluation Of Medicinal Plant Biological Activities: The Correlation Between Phytomics And Matrix Metalloproteinases Activities Of Some Medicinal Plants
(2019)Phytomics or metabolomics is analysis of large-scale primary and secondary metabolites of plant extracts and provides very meaningful data to monitor or evaluate cellular function or systems biology. The activity of plant ... -
A New Generation Of Dihydropyridine Calcium Channel Blockers: Photostabilization Of Liquid Formulations Using Nonionic Surfactants
(2019)The stability profile of a new 1,4-dihydropyridine derivative (DHP), representative of a series with a hexahydroquinoline ring, was studied to design light-stable liquid formulations. This molecule, named M3, has been shown ... -
Patterns Of Endemism In Turkey, The Meeting Point Of Three Global Biodiversity Hotspots, Based On Three Diverse Families Of Vascular Plants
(2019)Centers of endemism and areas of endemism are important biogeographic concepts with high relevance for conservation and evolutionary biology. Turkey is located at the intersection of three global biodiversity hotspots ... -
Discovery And Characterisation Of Dual Inhibitors Of Tryptophan 2,3-Dioxygenase (Tdo2) And Indoleamine 2,3-Dioxygenase 1 (Ido1) Using Virtual Screening
(2019)Cancers express tryptophan catabolising enzymes indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2) to produce immunosuppressive tryptophan metabolites that undermine patients’ immune systems, leading ...
RSS 1.0