Browsing Temel Eczacılık Bilimleri Bölümü Makale Koleksiyonu by Issue Date
Now showing items 41-60 of 123
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Monitoring The Perturbation Of Soil And Groundwater Microbial Communities Due To Pig Production Activities
(Amer Soc Microbiology, 2013)This study aimed to determine if biotic contaminants originating from pig production farms are disseminated into soil and groundwater microbial communities. A spatial and temporal sampling of soil and groundwater in proximity ... -
Polyproline Tetramer Organizing Peptides in Fetal Bovine Serum Acetylcholinesterase
(Elsevier Science Bv, 2013)Acetylcholinesterase (AChE) in the serum of fetal cow is a tetramer. The related enzyme, butyrylcholinesterase (BChE), in the sera of humans and horse requires polyproline peptides for assembly into tetramers. Our goal was ... -
Rp-Hplc Method Development and Validation for Estimation of Rivaroxaban in Pharmaceutical Dosage Forms
(Univ Sao Paulo, Conjunto Quimicas, 2013)Rivaroxaban, an anti-clotting medication, acts at a crucial point in the blood-clotting process and stops the formation of blood clots. In this study, RP-HPLC method was developed for the determination of rivaroxaban in ... -
Synthesis of New 2-(N'-Allylidene-Hydrazino) Quinazolinones and 2-(4,5-Dihydropyrazolyl)-Quinazolinones and Their Antimicrobial and Antifungal Activity Screening
(Asian Journal Of Chemistry, 2014)Novel 2-[N'-(1,3-disubstituted-phenyl) allylidene] hydrazine-3-ethyl-3H-quinazolin-4-one (8) and 2-(3,5-disubstituted-phenyl-4,5-dihydropyrazol- 1-yl)-3-ethyl-3H-quinazolin-4-one (9) compounds have been prepared and tested ... -
Uv Spectrophotometric Method For Determination Of The Dissolution Profile Of Rivaroxaban
(Dissolution Technologies, Inc, 2014)Rivaroxaban is an oral anticoagulant that is the first available orally active direct Factor Xa inhibitor. In this study, a UV spectrophotometric method was developed for the determination of rivaroxaban content in ... -
Capillary Electrophoresis For Total Glycosaminoglycan Analysis
(Springer Heidelberg, 2014)A capillary zone electrophoresis-laser-induced fluorescence detection (CZE-LIF) method was developed for the simultaneous analysis of disaccharides derived from heparan sulfate, chondroitin sulfate/dermatan sulfate, ... -
Caffeic Acid Phenethyl Ester As a Protective Agent Against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review
(2014)Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, ... -
Evaluation Of A Capillary Electrophoresis Method For Routine Determination Of Varenicline Tartrate In Quality-Control Laboratories
(Soc Chemists Technologists Madeconia, 2015)In this study, analyses were carried out on a fused-silica capillary (i.d. 50.0 mu m, total length 48.5 cm, and effective length 40.0 cm) in normal mode by applying a voltage of 20 kV. Sample injections were made in ... -
Modulation Of Mitochondrial Complex I Activity Averts Cognitive Decline In Multiple Animal Models Of Familial Alzheimer'S Disease
(2015)Development of therapeutic strategies to prevent Alzheimer's disease (AD) is of great importance. We show that mild inhibition of mitochondrial complex I with small molecule CP2 reduces levels of amyloid beta and phospho-Tau ... -
Plasma 8-Isopgf2 Alpha and Serum Melatonin Levels in Patients with Minimal Cognitive Impairment and Alzheimer Disease
(Tubitak Scientific & Technical Research Council Turkey, 2015)Background/aim: F2 alpha-isoprostane is accepted as an oxidative stress indicator and melatonin shows neuroprotective effects by antioxidative and antiamyloidogenic influences. By measuring these in patients diagnosed with ... -
Development of Sensitive And Specific Analysis of Vildagliptin In Pharmaceutical Formulation By Gas Chromatography-Mass Spectrometry
(2015)A sensitive and selective gas chromatography-mass spectrometry (GC-MS) method was developed and fully validated for the determination of vildagliptin (VIL) in pharmaceutical formulation. Prior to GC-MS analysis, VIL was ... -
Induction Of Telomere Dysfunction Mediated By The Telomerase Substrate Precursor 6-Thio-2'-Deoxyguanosine
(Amer Assoc Cancer Research, 2015)The relationships between telomerase and telomeres represent attractive targets for new anticancer agents. Here, we report that the nucleoside analogue 6-thio-2'-deoxyguanosine (6-thio-dG) is recognized by telomerase and ... -
Rutin Ameliorates Methotrexate Induced Hepatic Injury in Rats
(Acta Cirurgica Brasileira, 2015)PURPOSE: To investigate the possible protective effect of rutin on methotrexate induced hepatotoxicity in rats. METHODS: Twenty-two rats were divided into three experimental groups; Control-saline, Mtx, Mtx+Rutin. Hepatic ... -
Specimen Rejection In Laboratory Medicine: Necessary For Patient Safety?
(2015)Introduction The emergency laboratory in Hacettepe University Hospitals receives specimens from emergency departments (EDs), inpatient services and intensive care units (ICUs). The samples are accepted according to the ... -
Comparative Proteomics To Investigate The In Vitro Antiproliferative Effect Of Dietary Polyphenols Against K562 Leukemia Cells
(Walter De Gruyter Gmbh, 2015)Objective: The lack of success with classical targeted therapies in cancer treatment has forced researchers to employ either combined therapies or agents that interfere with multiple pathways. In this study, a proteomic ... -
Cardiac Resynchronization Therapy Induces Adaptive Metabolic Transitions in the Metabolomic Profile of Heart Failure
(Churchill Livingstone Inc Medical Publishers, 2015)Background: Heart failure (HF) is associated with ventricular dyssynchrony and energetic inefficiency, which can be alleviated by cardiac resynchronization therapy (CRT). The aim of this study was to determine the metabolomic ...
