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Curcumin-Based Pyrazoline Analogues As Selective Inhibitors Of Human Monoamine Oxidase A 

Nath, Chandrani; Badavath, Vishnu Nayak; Thakur, Abhishek; Ucar, Gulberk; Acevedo, Orlando; Siddique, Mohd Usman Mohd; Jayaprakash, Venkatesan (Royal Soc Chemistry, 2018)
A series of 2-methoxy-4-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)phenol (pyrazoline) derivatives (2-6) have been synthesized and tested for human monoamine oxidase (hMAO) inhibitory activity. The most active derivative (2) ...

Differential Requirement For The Atpase Domain Of The Cockayne Syndrome Group B Gene In The Processing Of Uv-Induced Dna Damage And 8-Oxoguanine Lesions In Human Cells 

Selzer, RR; Nyaga, S; Tuo, JS; May, A; Muftuoglu, M; Christiansen, M; Citterio, E; Brosh, RM; Bohr, VA (Oxford Univ Press, 2002)
Cockayne syndrome (CS) is a rare inherited human genetic disorder characterized by UV sensitivity, developmental abnormalities and premature aging. The cellular and molecular phenotypes of CS include increased sensitivity ...

Effects Of Cadmium And Zinc Ions On Purified Lamb Kidney Cortex Glucose-6-Phosphate Dehydrogenase Activity 

Tandogan, Berivan; Ulusu, Nuray N. (Taylor & Francis Ltd, 2006)
Glucose-6-phosphate dehydrogenase (G-6-PD) is the first enzyme in the pentose phosphate pathway. Cadmium is a toxic heavy metal that inhibits several enzymes. Zinc is an essential metal but overdoses of zinc have toxic ...

Misincorporation Of Free M-Tyrosine Cytotoxic Mechanism For Oxidized A Into Cellular Proteins: A Potential Amino Acids 

Gurer-Orhan, H; Ercal, N; Mare, S; Pennathur, S; Orhan, H; Heinecke, JW (Portland Press Ltd, 2006)
In vitro studies demonstrate that the hydroxyl radical converts L-phenylalanine into in-tyrosine, an unnatural isomer of L-tyrosine. Quantification of m-tyrosine has been widely used as an index of oxidative damage in ...

An Artificial Intelligent Diagnostic System on Differential Recognition of Hematopoietic Cells From Microscopic Images 

Beksaç, M; Beksaç, MS; Tipi, VB; Duru, HA; Karakaş, MU; Çakar, AN (Wiley-Liss, 1997)
Despite their advantages, none of the automated white blood cell differential counters have replaced the conventional microscopic evaluations of blood and bone marrow slides by hematologists, We have analyzed the smears ...

P-31 Nmr Correlation Maps Of O-18/O-16 Chemical Shift Isotopic Effects For Phosphometabolite Labeling Studies 

Juranic, Nenad; Nemutlu, Emirhan; Zhang, Song; Dzeja, Petras; Terzic, Andre; Macura, Slobodan (Springer, 2011)
Intramolecular correlations among the O-18-labels of metabolic oligophosphates, mapped by J-decoupled P-31 NMR 2D chemical shift correlation spectroscopy, impart stringent constraints to the O-18-isotope distributions over ...

Solid-Phase Enzyme Modification Via Affinity Chromatography 

Baran, ET; Ozer, N; Hasirci, V (Elsevier Science Bv, 2003)
In the present study antileukemic enzyme L-asparaginase (ASNase) and catalase (as a model enzyme) were modified in solid-phase with activated polyethylene glycol (PEG,) by using ligand-immobilized affinity column systems ...

Investigating the Structural Influence of Surface Mutations on Acetylcholinesterase Inhibition by Organophosphorus Compounds and Oxime Reactivation 

Kucukkilinc, Tuba; Cochran, Rory; Kalisiak, Jaroslaw; Garcia, Edzna; Valle, Anne; Amitai, Gabi; Radic, Zoran; Taylor, Palmer (Elsevier Ireland Ltd, 2010)
Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Binary mixtures of mammalian AChE and oximes of varying structure have ...

In Vivo And In Vitro Effects Of A Hif-1 Alpha Inhibitor, Rx-0047 

Dikmen, Z. Gunnur; Gellert, Ginelle C.; Dogan, Palkize; Yoon, Heejeong; Lee, Young Bok; Ahn, Chang Ho; Shay, Jerry W. (Wiley, 2008)
HIF-1 alpha plays a major role in activating gene transcription and is important for maintaining homeostasis under hypoxic conditions. Since tumors are often in a hypoxic state, HIF-1 alpha is a potential target for the ...

Polyproline Tetramer Organizing Peptides in Fetal Bovine Serum Acetylcholinesterase 

Biberoglu, Kevser; Schopfer, Lawrence M.; Saxena, Ashima; Tacal, Ozden; Lockridge, Oksana (Elsevier Science Bv, 2013)
Acetylcholinesterase (AChE) in the serum of fetal cow is a tetramer. The related enzyme, butyrylcholinesterase (BChE), in the sera of humans and horse requires polyproline peptides for assembly into tetramers. Our goal was ...
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AuthorAltinoz, Sacide (2)Biberoglu, Kevser (2)Lockridge, Oksana (2)Schopfer, Lawrence M. (2)Tacal, Ozden (2)Acevedo, Orlando (1)Ahn, Chang Ho (1)Amitai, Gabi (1)Badavath, Vishnu Nayak (1)Baran, ET (1)... View MoreSubject
Biochemistry & Molecular Biology (17)
Chemistry (4)Cell Biology (3)Pharmacology & Pharmacy (3)Biophysics (1)Spectroscopy (1)Toxicology (1)... View MoreDate Issued2010 - 2018 (9)2000 - 2009 (6)1997 - 1999 (2)Has File(s)Yes (17)

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