Eczacılık Fakültesi
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Melanomanın Topikal Yolla Tedavisine Yönelik Metformin Yüklü Polikaprolakton Nanopartikül İçeren Jel Formülasyonu Hazırlanması ve İn Vitro Değerlendirilmesi,
(Sağlık Bilimleri Enstitüsü, 2023-09)Melanoma is one of the most challenging types of cancers to treat with a high metastatic capability. Resistance to chemotherapeutic drugs used in melanoma treatment leads to reduced treatment efficacy. Furthermore, systemic ... -
Akciğer kanseri tedavisinde kullanılmak üzere nanopartikül içeren kuru toz inhalerformülasyonu hazırlanması, karakterizasyonu ve in vitro değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2023)In this thesis, the aim was to develop a dry powder inhaler formulation containing gefitinib nanoparticles for the treatment of non-small cell lung cancer. Gefitinib nanoparticles, below 130 nm in size, were prepared using ... -
Vinca soneri Koyuncu Üzerinde Farmakognozik Araştırmalar
(Sağlık Bilimleri Enstitüsü, 2023-09-08)Uyanır, E., Pharmacognostical investigation on Vinca soneri Koyuncu, Hacettepe University, Graduate School of Health Sciences, Pharmacognosy Programme, Master of Sciences Thesis, Ankara, 2023. Vinca soneri Koyuncu sp. nova ... -
MOMORDICA CHARANTIA L. EKSTRELERİNİN İÇERİĞİNİN VE MELANOMA KANSER HÜCRELERİ ÜZERİNE ETKİSİNİN METABOLOMİK ÇALIŞMALARLA İNCELENMESİ
(Sağlık Bilimleri Enstitüsü, 2023-08)In this thesis study, Momordica charantia L. (bitter gourd) used in wound healing was investigated at the metabolome level with metabolomic studies based on Liquid Chromatography/Quadrapol Time-of-Flight Mass Spectrometry ... -
INULA FRAGILIS BOISS. & HAUSSKN. ÜZERİNDE FARMAKOGNOZİK ARAŞTIRMALAR
(Sağlık Bilimleri Enstitüsü, 2023)Uzun, K., Pharmacognosical studies on Inula fragilis Boiss. & Hausskn., Hacettepe University, Graduate School of Health Sciences, Pharmacognosy Program, PhD Thesis, Ankara, 2023. Inula L. (Asteraceae) species are rich in ... -
ANTİVİRAL ETKİLİ FAVİPİRAVİR’İN YEŞİL KROMATOGRAFİ İLE ANALİZİ
(Sağlık Bilimleri Enstitüsü, 2023)Among the scientific researches carried out today, the green chromatography technique, which has been developed to carry out analyzes that prioritize environmental and human health safety, has an important place. Green ... -
Statin Tedavisinin Kılavuza Uygunluğunun ve Hasta Uyuncunun Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2023)Kızıldağ, B., Evaluation of Compliance with Guidelines and Patient Adherence of Statin Therapy, Hacettepe University Graduate School of Health Sciences, Master Thesis in Clinical Pharmacy, Ankara, 2023. Atherosclerotic ... -
DÜNYADA YENİ AŞI ÜRETİMİNDE UYGULANAN TOKSİKOLOJİK DEĞERLENDİRMELERİN KARŞILAŞTIRILMASI
(Sağlık Bilimleri Enstitüsü, 2023)Vaccines are complex biological medicinal products containing components such as antigens, adjuvants, and preservatives. They prevent diseasesby stimulating the immune system and providing active immunity. In the last ... -
Synthesis and Investigation of Tyrosinase Inhibitory Activity of Some New Benzimidazole Derivatives
(Sağlık Bilimleri Enstitüsü, 2023)4 new 2-(4-(1H-benzimidazol-1-yl)phenyl)-3-(substitutedphenylamino)thiazolidin-4-one (2a-d) and 7 new 2-(4-(1H-benzimidazol-1-yl)phenyl)-3-(substitutedphenyl)thiazolidin-4-one (3a-g) were synthesized and their tyrosinase ... -
Siklofosfamid ile İndüklenmiş Fare Sistit Modelinde Agonist ile İndüklenen Kasılma Yanıtlarındaki Bozulmada Hidrojen Sülfür ile Reaktif Oksijen Türevlerinin Rolü ve Etkileşimi
(Sağlık Bilimleri Enstitüsü, 2023)Interstitial cystitis is a syndrome characterized by sensory and motor dysfunction of the lower urinary tract. Hydrogen sulfide is an endogenously produced gasotransmitter and is responsible for regulating many functions. ... -
GADOTERAT MEGLUMİN’İN BOZUNMA ÜRÜNLERİNİN VARLIĞINDA YÜKSEK BASINÇLI SIVI KROMATOGRAFİSİ İLE ANALİZLERİ
(Sağlık Bilimleri Enstitüsü, 2023)Gadolinium contrast agents are chemicals used in magnetic resonance imaging. When injected into the body, gadolinium contrast agent enhances and improves the quality of magnetic resonance imaging. These substances are ... -
NEFROLOJİ POLİKLİNİĞİNDE TAKİBİ YAPILAN HASTALARDA SODYUM-GLUKOZ KO-TRANSPORTER 2 (SGLT-2) İNHİBİTÖRLERİNİN KULLANIMININ DEĞERLENDİRİLMESİ
(Sağlık Bilimleri Enstitüsü, 2023-08-08)Ozturk, Z., Evaluation of the Use of Sodium-Glucose Co-Transporter 2 (SGLT-2) Inhibitors in Patients Followed Up in the Nephrology Outpatient Clinic, Hacettepe University Graduate School of Health Sciences, Master Thesis ... -
Deneysel alerjik astım modelinde mitokondri hedefli hidrojen sülfür donörü AP39 tedavisinin etkisinin araştırılması
(Sağlık Bilimleri Enstitüsü, 2023)In this thesis, the effect of AP39, which is a mitochondria targeted slow releasing hydrogen sulfide (H2S) donor, were investigated in a mouse model of ovalbumin (OVA)-induced allergic asthma. In this model, experimental ... -
YENİ HEKZAHİDROKİNOLİN TÜREVLERİNİN SENTEZİ, KARAKTERİZASYONU, SİTOTOKSİSİTE, İNTRASELLÜLER ROS ÜRETİMİ VE ENFLAMASYON MEDİYATÖRLERİNE İNHİBİTÖR ETKİLERİNİN SAPTANMASI
(Sağlık Bilimleri Enstitüsü, 2023-07-14)In this study, 15 compounds with the general structure of hexahydroquinoline-3-carboxylate, a condensed derivative of 1,4-DHP, which are expected to show inhibitory activity on inflammatory mediators, were synthesized. The ... -
Türkiye’de Yetişen Rumex Türleri Üzerinde Hplc ile Kemotaksonomik Araştırmalar ve Temel Bileşen Analizi
(Sağlık Bilimleri Enstitüsü, 2023)This thesis aims to comparatively determine the chemical content of the root, leaf, and inner perianth of 20 Rumex L. species naturally grown in Turkey and perform targeted metabolomics analysis and principal component ... -
Kardiyak Cerrahi Hastalarında Preoperatif ve Postoperatif Dönemde Risk Analizi ile İlaç Tedavisinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2023)This study aimed to identify drug related problems (DRPs), analyze the risks and evaluate the impact of a clinical pharmacist in risk management process of cardiac surgery. Prospective, quasi-experimental study was conducted ... -
Metal Geri Dönüşüm Sektörü Çalışanlarında Kurşun Maruziyetinin Neopterin Düzeylerine Etkisi
(Sağlık Bilimleri Enstitüsü, 2023)Muhammetli S., The Effect of Lead Exposure on Neopterin Levels in Metal Recycling Industry Workers, Hacettepe University Graduate School of Health Sciences Pharmacy Department of Pharmaceutical Toxicology Program Master of ... -
Rasajilin İçeren Ağızda Dağılan Tablet Formülasyonlarının Geliştirilmesi, İn Vitro ve İn Vivo Değerlendirilmesi.
(Sağlık Bilimleri Enstitüsü, 2023)Parkinson's disease is a neurodegenerative disease of the nervous system, in which mostly motor movements, speech and other functions are impaired. Because of the role of the MAO-B enzyme in dopamine metabolism, MAO-B ... -
Lavandula stoechas L. subsp. stoechas Üzerinde Biyolojik Aktivite Rehberli Çalışmalar
(Sağlık Bilimleri Enstitüsü, 2023)Lavandula stoechas L. subsp. stoechas known as “karabaş otu” is used for diabetes and central nervous system disorders. This thesis focuses on scientifically validating the traditional usage of L. stoechas subsp. stoechas ... -
Eroinin glutatyon metabolizması üzerindeki etkisinin metabolomik düzeyde araştırılması
(Sağlık Bilimleri Enstitüsü, 2023)Heroin is a substance that is a synthetic opioid derivative with a high addictive potential. Serious toxic effects may occur due to heroin use. Although many different mechanisms are effective in the emergence of these ...
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