Browsing Temel Tıp Bilimleri Bölümü Tez Koleksiyonu by Title
Now showing items 123-142 of 324
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Immunomodulatory Effects of Novel Immune Costımulator Sa-4-1bbl In Nnk-Induced Lung Cancer Preclınıcal Model
(Sağlık Bilimleri Enstitüsü, 2024-07-09)Immune checkpoint inhibitors hold promise in treating various malignancies, but their use is limited due to side effects and treatment resistance. Therefore, the immune costimulation pathway is an important target to enhance ... -
Improvement of Germ Stem Cell Pool by Leptin Supplementation and Gene Editing for Male Infertility
(Sağlık Bilimleri Enstitüsü, 2020-06-12)Infertility affects up to 12-15% of sexually active couples, and male factors contribute about 30-55% of these cases. Infertility can be caused by injuries, genetic factors, exposure to toxicants, immune-suppressive and ... -
Intern Doctors’ Likelihood of Speakıng Up For Patient Safety
(Sağlık Bilimleri Enstitüsü, 2019-09)Communication breakdowns make significant contributions to medical errors and adverse events in health care. Speak up about patient safety creates a safe atmosphere which is vital to keeping patients safe, preventing errors, ... -
Investigating the Effects of Neurometabolic Disease-Causing Genes on Synapse Function in Drosophila melanogaster
(Sağlık Bilimleri Enstitüsü, 2022)Our group has identified several patients that harbor mutations in genes that hold the potential for being important players of synapse function, UNC79 and MBOAT7 being two of them. UNC79 is one of the accessory ... -
Investigation of the Role of LAP1B in Transcriptional Regulation of Muscle Cells
(Sağlık Bilimleri Enstitüsü, 2021-01-20)The loss-of-function of the inner nuclear membrane protein LAP1B (lamina-associated polypeptide 1, isoform B) causes muscular dystrophy and cardiomyopathy in humans. The function of LAP1B in muscle is still unknown. The ... -
Investıgatıon of The In Vıtro And In Vıvo Effects of Telomere-Targeted New Drug Candıdate Compounds on Dıfferent Cancer Cell Lınes
(Sağlık Bilimleri Enstitüsü, 2023)Cancer, characterized by its heterogeneity, metastatic character, and limited treatability, stands as a leading global cause of mortality. Cancer cells elongate their telomeres through the activity of the telomerase enzyme, ... -
İkinci Trimesterde Sağlıklı Ve Kromozomal Anomalili Gebeliklerde Fetal Nazal Kemik, Ense Katlantısı, Böbrek, Karaciğer, Barsak, Plasenta ve Maternal Uterus Kas Tabakasının B-Mod Histogram ve Shear Wave Elastogram Yöntemleri ile İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2023)B-mode ultrasonography is utilized in fetal screening of chromosomal abnormalities like Down Syndrome. Presence of soft markers such as hyperechogenic bowel, renal pelviectasis, hypoplastic nasal bone and increased nuchal ... -
İlaç Yeniden Konumlandırma Yaklaşımı ile Alfa Tübülin Asetilasyonunu Arttırabilecek Bileşiklerin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2020)Drug repurposing approach is used to identify new indications of drugs outside the scope of their original indications. This approach has been used to identify effective compounds for neurodegenerative diseases. Axonal ... -
Bir İlde Kamuda Görevli Sağlık Çalışanlarının İş Güvenliği İklimi ve İş Yerinde COVID-19 Yakın Temaslı Olma Durumunun Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2024-07-05)Healthcare workers frequently come into high-risk contact with COVID-19 cases. In other words, they are being in close contact with COVID-19. This study examined the relationship between healthcare workers' close contact ... -
İleri Yaşam Desteği Simülasyonunun Tıp Fakültesi Son Sınıf Öğrencilerinin Özyeterlik Algısına Etkisinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2021)Evaluation Of The Effect Of Advanced Life Support Simulation On Final-Year Medical Students' Self-Efficacy Perceptions, Hacettepe University, Graduate School of Health Sciences, Medical Education Doctoral Thesis, Ankara, ... -
İnflamasyon İle İlişkili Nöromüsküler Hastalıklarda Dolaşımdaki Mitokondriyal DNA'nın Araştırılması
(Sağlık Bilimleri Enstitüsü, 2019)Neuromuscular diseases, mostly being among the rare genetic diseases, include a wide range of syndromes and diseases in which directly or indirectly skeletal muscle structure and function are affected. Recent scientific ... -
İnflamatuvar Hücre Göçü Sürecinde Pyrin ve Aktin İle Ilişkili Proteinlerin Moleküler Analizi
(Sağlık Bilimleri Enstitüsü, 2014)MEFV gene, encodes Pyrin protein, cause familial Mediterranean fever (FMF). Pyrin which is primarily expressed in neutrophils and monocytes, appears to be a regulator of inflammation, but its exact role on FMF pathophysiology ... -
İnsan Granüloza Hücresi Mitokondriyon Fonksiyonu ile AMH ve Östrojen İlişkisi
(Tıp Fakültesi, 2021)Anti-Müllerian Hormone (AMH) and estrogen are essential hormones in human ovarian folliculogenesis. AMH and estrogen are produced by granulosa cells. It is known that mitochondria in human granulosa cells are important for ... -
İnsan Kaynaklı Kistik Ekinokokkozis'in Moleküler Epidemiyolojisi
(Sağlık Bilimleri Enstitüsü, 2017)Cystic Echinococcosis (CE) is a zoonotic disease caused by larval forms of parasites of the genus Echinococcus in humans. CE is one of the most common zoonotic diseases in the world, particularly in regions where the local ... -
İnsan Serebral Mikrovasküler Endotel Hücrelerinin T Hücre Ko-İnhibisyonuna Etkisi
(Sağlık Bilimleri Enstitüsü, 2022)With continuous stimulation, naive T helper cells (Th) convert into effector and exhausted Th cells with low cytokine production and proliferation capacity. In addition, during this differentiation process, there are ... -
İnsan Serum Bütirilkolinesterazının Olası Lipolitik Aktivitesi-Lipid Metabolizması ile İlişkisi.
(Sağlık Bilimleri Enstitüsü, 2021-01-21)Cholinesterases (AChE and BChE) terminate acetylcholine-induced neurotransmission at cholinergic synapses in muscle-nerve junctions. We previously showed BChE expression is regulated by essential fatty acids. The similarity ... -
İnterstisyel Akciğer Hastalığı Tanısı ile İzlenen Hastaların İmmünolojik Özelliklerinin Değerlendirilmesi
(Çocuk Sağlığı Enstitüsü, 2024)Childhood Interstitial Lung Diseases (chILD) are a heterogeneous group of chronic respiratory diseases with usually no identifiable etiology. This disease group is rare and exhibits heterogeneous characteristics, showing ... -
İntörn Hekimlerin Tükenmişlik Durumları, Akademik Başarıları, Eğitim Ortamı Algıları ve Öğrenme Yaklaşımlarının Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2023)In this study we aimed to determine the relation between the burnout status and sosciodemographical factors in the students beginning to the sixth year of education in Zonguldak Bülent Ecevit University School of Medicine ... -
İnvasiv Duktal Meme Karsinoması ile İlişkili Yanlış Anlamlı Mutasyonların Olası Yapısal ve Fonksiyonel Etkilerinin In Silico Tahmini ve Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2018)Invasive Ductal Breast Carcinoma is an important problem in our country as it is in all over the world. For in situ breast cancer patients, the five-year survival rate is 52%, while for metastatic breast cancer patients ... -
İstanbul İli ve Çevresinde Toplanan Kenelerde, Nairo, Flebo ve Flavivirusların Araştırılması
(Sağlık Bilimleri Enstitüsü, 2020)Emanet, N., Investigation of Nairo, Phlebo and Flavivirus in Ticks Collected around Istanbul Province Hacettepe University Graduate School Health Scıences, MSc, thesis in Microbiology, Ankara, 2020. In this study, we ...
